Stroke
Conditions
Keywords
transcranial direct current stimulation, dual stimulation
Brief summary
The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of motor function in post stroke patients. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through three conditions of transcranial direct current stimulation with for 30 minutes. Three conditions are 1) Dual stimulation 1: i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area. 2) Dual stimulation 2: i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional anterior intraparietal sulcus and cathodal stimulation on contralesional supraorbital area. 3) Single stimulation: anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex.
Interventions
DEVICEM1 stimulation
stimulating primary motor cortex with anodal transcranial direct current stimulation
DEVICEPMC stimulation
stimulating premotor cortex with anodal transcranial direct current stimulation
DEVICEaIPS stimulation
stimulating anterior intraparietal sulcus with anodal transcranial direct current stimulation
BEHAVIORALhand motor task
hand motor task for 30 minutes during transcranial direct current stimulation
Sponsors
Samsung Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* unilateral hemiplegic stroke patient * Fugl Meyer Assessment score between 9 to 84
Exclusion criteria
* difficult to understand experimental tasks because of extremely severe cognitive impairment * history of psychiatric disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in motor evoked potentia | Baseline and after intervention (approximately 2 weeks) | measure the motor threshold and amplitude of motor evoked potential in first dorsal interosseous muscle. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes in nine hole peg test | Baseline and after intervention (approximately 2 weeks) | Nine-Hole Peg Test is used to measure finger dexterity in patients with various neurological diagnoses. |
| changes in grip and tip pinch strength test | Baseline and after intervention (approximately 2 weeks) | measure the hand strength (grip and tip pinch) |
| changes in box and block test | Baseline and after intervention (approximately 2 weeks) | box and block test measures unilateral gross manual dexterity |
| Changes in brain activation of resting-state functional MRI | Baseline and after intervention (approximately 2 weeks) | Neuroplasticity measure |
| Changes of Cortical activation | Baseline and after intervention (approximately 2 weeks) | Cortical activation is measured by functional Near-Infrared-Spectroscopy (fNIRS) (NIRScout, NIRx, Germany) |
Countries
South Korea
Outcome results
None listed