Lung Cancer and Idiopathic Pulmonary Fibrosis
Conditions
Keywords
Lung cancer; Idiopathic pulmonary fibrosis
Brief summary
Retrospective inclusion of lung cancers developed in a context of idiopathic pulmonary fibrosis, diagnosed and / or treated in participating centers. The cases are recovered retrospectively from the records of the pulmonology and pathology departments of our various partners.
Detailed description
Primary objective: Characterize altered molecular pathways in lung cancer in patients with IPF versus lung cancer in non-IPF patients. Secondary objectives: Identify specific therapeutic targets Describe a cohort of lung cancers on IPF (clinical / radiological and pathological data) To study the relationship between neoplastic / preneoplastic lesions and pulmonary parenchyma reshaped by fibrosis.
Interventions
None listed
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Lung carcinoma * Idiopathic pulmonary fibrosis
Exclusion criteria
\- No tumor sample available
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Molecular profile of IPF-associated lung carcinomas | 1 month / 8 samples | Next generation sequencing of carcinomas with Ion S5 XL sequencer and Oncomine™ Comprehensive Panel |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pathological characterization of lung carcinomas | 1 month / 8 samples | Histological classification of carcinomas and immunohistochemistry with lineage markers |
Countries
France
Outcome results
None listed