People Living With HIV/AIDS, Nitrate, Endotelial Function, Arterial Stiffness and Skeletal Muscle Oxygenation

Effect of Ingestion of Beet Juice on Endothelial Function, Arterial Stiffness and Muscle Oxygenation Parameters in People Living With HIV / AIDS Using Antiretroviral Therapy

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03485248

Enrollment

Registered

2018-04-02

Start date

2017-10-18

Completion date

2018-11-28

Last updated

2019-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV/AIDS

Keywords

HIV/AIDS, Arterial stiffness, Flow mediated-dilatation, Muscle oxygenation parameters, Microcirculation, Dietary Nitrate

Brief summary

Administration of antiretroviral therapy has brought benefits for infective human immunodeficiency virus-1 (HIV-1)-patients, reducing the number of AIDS-related morbidity and mortality. However, it is responsible for intensifying complications triggered by the chronic inflammatory state associated with virus infection, such as cardiovascular diseases. The current study evaluated effects of single dose (140mL) of Beetroot Juice (BJ) on macro and microvascular endothelial function in HIV-1-patients undergoing antiretroviral terapy, once BJ was shown to be effective in improving these physiological parameters in uninfected individuals.

Interventions

DIETARY_SUPPLEMENTBeetroot Juice

140ml of Beetroot Juice containing on avarege 9 mmol of nitrate

DIETARY_SUPPLEMENTPlacebo

140ml of Beetroot Juice (nitrate free)

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Masking description

Double- Blind

Eligibility

Sex/Gender

ALL

Age

18 Years to 59 Years

Healthy volunteers

Yes

Inclusion criteria

* HIV infection for a period of 1 year or greater * Regular use of high-potency antiretroviral therapy for at least one year

Exclusion criteria

* Individuals who are physically active * Individuals who are allergic to some component of beet * Individuals who use nutritional and / or pharmacological ergogenics * Individuals receiving antibiotics or who have osteomioarticular problems

Design outcomes

Primary

Measure	Time frame	Description
Skeletal Muscle Oxygenation	Baseline and approximately after 150 minutes of beetroot juice consumption	Changes in skeletal muscle oxygenation in response to exercise will be evaluated by using a near-infrared spectroscopy device.
Brachial artery flow-mediated dilatation	Baseline and approximately after 150 minutes of beetroot juice consumption	The brachial artery flow-mediated dilation will be evaluated by using an ultrasound device.

Secondary

Measure	Time frame	Description
Urinary nitrate concentrations	Baseline and approximately 30, 90, and 150 minutes after beetroot juice consumption	Analysis of nitrate in urine will be performed by using high-performance liquid chromatography system.

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 17, 2026