Migraine Disorders
Conditions
Brief summary
The purpose of this study is to determine whether reduced frequency of migraine attacks are associated with signal alternation and connectivity of cerebral cortex.
Detailed description
Patients with migraine show reduced cortical thickness in regions subserving pain processing, and it is related to increasing headache frequency. In the past, only one study has shown a reversibility consequence of chronic nociceptive transmission, which normalizes when the pain is adequately treated. However, little is known whether these changes predispose to migraine or represent the effect of repeated migraine attacks. Our region of interest is reduced frequency of migraine attacks are associated with reversibility of signal alternation and functional connectivity of cerebral cortex. In 30 migraineurs with 8-14days with headache per months who already performed brain magnetic resonance imaging will be recruited. Treatment medications such as frovatriptan and topiramate will be used for 6 months. After 6 months, follow-up brain magnetic resonance imaging will be performed. The primary outcome is the longitudinal changes in functional connectivity in pain-processing/modulating brain regions. The secondary outcome is following: 1)longitudinal changes in structural and morphological alterations in brain regions of pain processing; 2)structural, morphological, and functional correlates of treatment response; 3)changes in monthly migraine days, migraine frequecies, headache days, and headache frequencies after treatment; 4)responses to acute migraine treatment.
Interventions
None listed
Sponsors
SK Chemicals Co., Ltd.
Samsung Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Premenopausal Women * Aged 18-50 * Drug-naïve high frequency episodic migraineurs (8-14 attacks/m) * Performed a baseline interictal brain MRI
Exclusion criteria
* Medication overuse * Chronic pain other than migraine * On treatment of major depression, bipolar, schizophrenia, or BDI\>25
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| functional MRI imaging changes | 6 month | temporal changes in BOLD correlations in the regions of most significant correlation with periaqueductal grey; temporal changes in BOLD correlations in the regions of most significant correlation with anterior cingulate cortex; temporal changes in default mode network |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional and structural correlates of treatment response | 6 months | \>50% reduction of monthly headache days |
| structural MRI imaging changes | 6 months | changes in cortical thickness of anterior cingulate, amygdala, periquiductal grey, and sensorimotor cortex |
| correlation of functional MRI changes with changes in clinical parameters | 6 months | changes in monthly headache days |
| responses to acute migraine treatment | 6 months after the first visit | the Migraine Assessment of Current Therapy (Migraine-ACT) = 4 |
Countries
South Korea
Outcome results
None listed