The China Valvular Heart Disease Study

Conditions

Valvular Heart Disease

Brief summary

This is a observational、multicenter, prospective cohort study for adults with significant VHD. The purposes of this study were to evaluate the etiology、clinical characteristics、treatment modalities, and outcomes of patients with VHD；also to set up registration system of adult VHD in China, to build a database of Chinese adult VHD, to establish a web-based international standard data acquisition system for VHD and a multicenter clinical research platform. The results of the study will provide a basis for the future national health policy for prevention and treatment of adult VHD.

Chenyang Li, Yunqing Ye, Can Wang, Xiangming Hu, Junxing Lv et al. (12 authors)

BMC Cardiovascular Disorders2026-06-12

10.1186/s12872-026-06057-4

Ambient fine particulate matter exposure and prognosis in patients with valvular heart disease

Xiangming Hu, Yunqing Ye, Zhe Li, Qing‐Rong Liu, Z Zhao et al. (18 authors)

Heart2026-05-18

10.1136/heartjnl-2025-327619

Primary regional disparities in clinical characteristics, treatments, and outcomes of a typically designed study of valvular heart disease at 46 tertiary hospitals in China: Insights from the China-VHD Study

Xiangming Hu, Yunqing Ye, Zhe Li, Qing‐Rong Liu, Zhenyan Zhao et al. (19 authors)

Chinese Medical Journal2025-03-18

10.1097/cm9.0000000000003570

Prognostic Impact of Left Ventricular Ejection Fraction in Patients With Moderate Aortic Regurgitation: Potential Implications for Treatment Decision-Making

Qinghao Zhao, Bin Zhang, Yunqing Ye, Zhe Li, Qing‐Rong Liu et al. (18 authors)

Frontiers in Cardiovascular Medicine2022-01-1712 citations

10.3389/fcvm.2021.800961

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* patients over 60 years old meet one of the following conditions. 1. moderate or above valvular heart disease as defined by echocardiography: （1）aortic stenosis, moderate or above, or valve area ≤1.5cm2, or maximal jet velocity ≥3.0m/sec, or mean pressure gradient ≥20mmHg, （2）aortic regurgitation, moderate or above, or jet width ≥25% of left ventricular outflow tract, or regurgitant volume ≥30ml/beat, or regurgitant fraction ≥30%, （3）mitral stenosis, moderate or above, or valve area ≤1.5cm2, （4）mitral regurgitation, moderate or above, or effective regurgitant orifice ≥0.2cm2, or regurgitant volume ≥30ml/beat, or regurgitant fraction ≥30%, （5）tricuspid stenosis, moderate or above, or valve area ≤1.0cm2, （6）tricuspid regurgitation, moderate or above, or central jet area ≥5.0cm2, （7）pulmonic stenosis, moderate or above, or maximal jet velocity \>4m/sec, （8）pulmonic regurgitation, moderate or above, 2. or patients who had undergone any operation on a cardiac valve (percutaneous balloon commissurotomy, valve repair, valve replacement, transcatheter aortic valve implantation), 3. or diagnosis of endocarditis as assessed by Duke criteria.

Exclusion criteria

* Patients cannot be followed up for any reasons. Patients have been enrolled in this study.

Design outcomes

Primary

Measure	Time frame
all-cause mortality	2years

Countries

China

Outcome results