Endometrioma, Endometriosis
Conditions
Keywords
ovarian reserve, endometriosis, endometrioma
Brief summary
This study evaluates the optimum day of menstrual period for the excision of endometriomas to minimize the damage of surgery to normal ovarian tissue. Patients will be grouped as follicular, ovulatory and luteal according to menstrual days. Ovarian damage will be evaluated with both pathologic examination and anti-mullerian hormone levels before and after the surgery.
Detailed description
Endometriosis is a common gynecologic disease seen in about 10% of women in reproductive age. The most common site of endometriosis is overt. Cystic formation of ovarian endometriosis is called endometrioma (chocolate cyst). Definitive treatment of endometriomas is excision by laparoscopy. The disadvantage of this surgery is the removal of some of the normal ovarian follicles within cystectomy material. This procedure can damage the ovarian reserves with the treatment of endometriomas, which are already the cause of infertility, and lead to the conditions such as infertility or early menopause. It has been understood that the ovarian reserves of the patients who underwent endometrioma cystectomy with the decrease of the Anti-Mullerian Hormone values, which is an over reserve parameter.
Interventions
PROCEDURElaparoscopic endometrioma cyst excision
laparoscopic resection of ovarian endometrioma
Sponsors
Acibadem University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* 4 to 10 cm unilateral ovarian endometrioma * having clinically indication of laparoscopic ovarian endometrioma excision
Exclusion criteria
* prior gynecologic surgery * prior abdominal surgery * additional operation in the same session * having the diagnosis of premature ovarian failure or ovarian insufficiency * having any diagnosis of malignancy * having diagnosis of a non-gynecologic chronicle disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determination of ovarian follicle damage via histological examination | 5 days after the surgery | Histologic evaluation of the cystectomy excision material for health ovarian follicles |
| Change of anti-mullerian hormone level 6 months after surgery | 6 months | Comparison of pre-operative and 6 months after surgery of anti-mullerian hormone levels |
Countries
Turkey (Türkiye)
Outcome results
None listed