Healthy Volunteers
Conditions
Keywords
Gyrus Cinguli, Cognitive Control Process, Check process, Decision Making, fMRI
Brief summary
Effective exploration of the environment, check for information to improve one's own performance, are fundamental abilities of human cognition. These abilities are dependent on the process of cognitive control. However, they are clearly impaired and uncontrollable in certain behavioral disorders such as obsessive-compulsive disorder (OCD). Compulsive checks of these patients, spontaneously associated with a feeling of intense uncertainty, suggest disturbances of evaluative and metacognitive functions. However, no biological observations have yet been able to feed these hypotheses. The evaluation of decisions and actions involves the middle cingulate cortex (MCC) (which belongs to a cortico-subcortical network structurally and functionally altered in OCD patients). Cingulotomy has long been used as a therapy in severe OCD, with However, the precise part of the cingulate cortex that contributes to check (and its pathological forms) remains to be discovered. The purpose of this research campaign is to determine, through functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) in healthy human subjects: 1. the location and role of the MCC region involved in normal check decision processes, 2. determine the identity of the entire network involved
Interventions
OTHERfMRI and EEG study
fMRI and EEG study
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* adults age range 20-45 years * being able to provide a written consent form * having a social insurance * have a normal vision (with or without corrections) * Right-handed
Exclusion criteria
* Subjects with MRI contraindications (e.g. pacemaker, claustrophobia, metal in the body, etc…). * Pregnant subjects * Subjects with neurological history * Subjects must be willing to be advise in case of discovery of brain abnormality.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measuring changes in brain activity in regions of interest when performing cognitive tasks. | through study completion, an average of 3 years | Behavior: Measurement of reaction times of correct answer during cognitive task. fMRI and EEG: Brain activity signal, |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Calculation of the correlations in the regions of interest of the individual values of the Blood Oxygen Level Dependent (BOLD) signal with the data of the concentration of Acide γ-aminobutyrique (GABA) | through study completion, an average of 3 years | calculate with the bold signal (spectroscopy) |
| Calculation of the correlations in the regions of interest of the individual values of the Blood Oxygen Level Dependent (BOLD) signal with the data of the amplitude of the electrical signal (EEG) | through study completion, an average of 3 years | — |
Countries
France
Outcome results
None listed