Body Parameters as an Independent Predictor of Acute Pancreatitis

Body Parameters as an Independent Predictor of Acute Pancreatitis: A Propensity Score-matched Case-control Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03482921

Enrollment

1662

Registered

2018-03-29

Start date

2017-12-01

Completion date

2018-03-22

Last updated

2018-03-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Pancreatitis

Brief summary

This study is to assess the predictive significance of visceral adipose tissue (VAT) and visceral adipose tissue /skeletal muscle tissue ratio (VAT/SMT ratio) for the prognosis in acute pancreatitis (AP) patients.

Detailed description

Acute pancreatitis (AP) is a sudden inflammation of the pancreas. However, one-fifth of patients may develop severe complications with a mortality between 10%-20% It remains a difficulty to find an effective method for prediction of severity of AP at early stage. It is well-established that obesity (defined as body mass index\[BMI\]\>30kg/m2 by the World Health Organization) is a risk factor for AP and increases the incidence of systemic complication, motality. There are a lot of parameters related to saropenic obesity, including areas of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), skeletal muscle tissue (SMT), and VAT/SMT ratio. it is unclear which parameter is the best predictor of severe AP. Thus, this study is aimed to investigate the association between these parameters and AP severity and find the best predictor of AP.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Inclusion criteria

1. diagnosed with AP 2. age \>18 years

Exclusion criteria

1. age\<18years 2. missing data in the electronic medical record 3. history of AP

Design outcomes

Primary

Measure	Time frame	Description
Comparisons of variables according to AP severity	the physical examination data in the year of 2017	Comparisons of variables according to AP severity by one-way analysis of variance (ANOVA) and Likelihood Ratio
Relationships between VAT and severity outcomes Relationships between VAT and severity outcomes Relationships between VAT and severity outcomes Relationships between body parameters and severity outcomes	the physical examination data in the year of 2017	Relationships between VAT and severity outcomes by Likelihood Ratio

Countries

China

Outcome results