Dietary Habits, Endotoxemia
Conditions
Brief summary
The aim of the present study is to determine the effect of monosaccharides on intestinal barrier function in healthy subjects.
Detailed description
In the intervention study normal weight participants will receive defined amounts of monosaccharides for several days. Before and after intervention parameters of intestinal barrier function will be assessed.
Interventions
OTHERDietary Intervention
Participants receive different monosaccharides for a defined number of days.
Sponsors
Prof. Dr. Ina Bergheim
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
All participants receive all interventional diets.
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI \<25 kg/m2 * no kown history of metabolic disorders or fatty liver
Exclusion criteria
* food allergies or intolerances (esp. fructose intolerance and malabsorption) * renal insufficiency * chronic disease of the gastrointestinal tract * taking drugs affecting lipid or glucose metabolism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in parameters of intestinal barrier function | 1 week | Changes in endotoxin plasma levels |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in blood lipid levels | 1 week | Changes in triglyceride levels |
| Changes in Uric Acid levels | 1 week | Changes in Uric Acid blood levels |
| Changes in blood pressure | 1 week | Changes in systolic and diastolic blood pressure |
| Changes in markers for glucose metabolism | 1 week | Changes in fasting glucose and fasting insulin levels |
Outcome results
None listed