Appendicitis Acute
Conditions
Keywords
adult, appendectomy, appendicitis, local anesthesia, pain
Brief summary
Acute appendicitis is one of the most common acute abdomens that need surgical intervention. Laparoscopic surgery much decreases postoperative pain of wound, however, pain remains an important determinant of recovery after surgery. Intraoperative local anesthetic agent infiltrated locally into surgical wound to relieve postoperative pain is a feasible and safe method suggested in some literature. However, there is no routine use of this method in clinical practice because its benefit is still unknown. Besides, very few evidence could be found in literature review. To date, there is still no double blinded, prospective, randomized control trial addressing in evaluation of its interest. In this study, the investigators aim at investigating the benefit of wound infiltration with local anesthetic agent (bupivacaine) for laparoscopic appendectomy in adult. The study design is a double blind, prospective, randomized control trial with a 1:1 allocation ratio. Fifty adult patients with appendicitis will be included. The control group undergo laparoscopic appendectomy without wound infiltration with local anesthetic agent, the intervention group undergo laparoscopic appendectomy with wound infiltration with local anesthetic agent intraoperatively. The clinical characteristics, outcomes, and patient's satisfaction will be recorded and analyzed. The investigators hope this study can provide a high level evidence in pain management of patient undergo laparoscopic surgery.
Interventions
DRUGBupivacaine
Bupivacaine 5 mL subcutaneous injection to surgical wound during operation.
Sponsors
National Taiwan University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Including criteria: 1. Clinical diagnosis of appendicitis and undergo laparoscopic appendectomy 2. Age more than 20 years 3. Well comprehensive in speaking Chinese
Exclusion criteria
1. Age no more than 20 years 2. Pregnancy 3. Can not cooperate with evaluation 4. Convert to open surgical method, resect more organs than appendix 5. Using patient control analgesia 6. Allergy to local anesthetic agent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain score of surgical wound of the patient | within 24 hours after surgery | Using Visual Analog Score (from 0 to 10, 0 indicate no pain and 10 indicate maximal pain) to evaluate pain of surgical wound of the patient |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Satisfaction of the patient | up to one month after surgery | Using questionnaire to evaluate satisfaction of the patient about surgery and hospitalization. |
Countries
Taiwan
Outcome results
None listed