Renal Anemia Refractory to Erythropoietin

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03480178

Enrollment

Registered

2018-03-29

Start date

2019-01-31

Completion date

2019-05-31

Last updated

2019-01-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ESRD, Renal Anemia

Brief summary

This study evaluates the renal anemia refractory to Epo . in hemodialysis patients. all of participants will receive Epo. and identify various factors contributing to etiology of renal anemia in Epo- resistant patients.

Detailed description

Chronic kidney disease (CKD) is considered a public health problem worldwide with high incidence and prevalence rates.Anemia is one of the most frequent early complication of CKD. The main cause is erythropoietin (EPO) deficiency due to impaired kidney function However, other causes should be considered when the severity of anemia is inconsistent with the decrease in renal function; when there is evidence of iron deficiency or matching decreases in hemoglobin, leukopenia and/or thrombocytopenia are also found

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Inclusion criteria

* Patients greater than or equal to 18 years old with CKD on hemodialysis

Exclusion criteria

1. \- Evidence of infections especial of vascular access . 2. \- malnutrition and manifestation of iron, B12, folate and protein deficiency . 3. \- any underling cause as; * Hematologic malignances -Hemolytic anemia - * Aplastic anemia (infection and/or bleeding with anemia) * Solid tumors * Bleeding (skin ,mucosal ,orificial) * Evidence of mineral bone disease (CKD-MBD) * Others

Design outcomes

Primary

Measure	Time frame	Description
Renal anemia refractory to erythropoietin	1 months	1 .Measurement of Hemoglobin , feritin and reitculocyte of patient before treatmeant by Epo. 100IU per Kg per week-SC. 2- Assessment to measure of hemoglobin of patient after treatment

Secondary

Measure	Time frame	Description
Renal anemia refractory to erythropoietin	6MONTHS	1 .Measurement of Hemoglobin of patient by CBC before treatmeant by Epo. 100IU per Kg per week-SC? 2- Assessment to hemoglobin of anemic patient during the specified post -dose period ,6months

Contacts

Primary Contactzaher alwi, master

binalwi2009@gmail.com01020361266

Backup ContactMohamed Sabah, prof.

Mohamedabbassobh@gmail.com01069272662

Outcome results