Keratoconjunctivitis, Meibomian Gland Dysfunction, Ocular Rosacea
Conditions
Keywords
Ocular Rosacea, Keratoconjunctivitis, Meibomian Gland, Interferometry, Child
Brief summary
The aim of this study is to describe the clinical, meibographic and interferometric manifestations of phlyctenular keratitis in children.
Detailed description
The investigators are conducting a monocentric, transversal, epidemiologic study. 100 patients should be included: 50 children suffering from ocular rosacea, and 50 children with no palpebral or Meibomian disease. Witnesses will be matched on the age of the cases. Patient and controls will undergo a classic ophthalmologic examination with visual acuity measurement and slit lamp examination of both eyes and eyelids. Then, the child will go through a meibographic and interferometric evaluation of his two inferior eyelids. This evaluation is made by an optometrist with the Lipiview device, and lasts a few minutes.
Interventions
PROCEDUREOphthalmologic examination and meibographic and interferometric evaluation (Lipiview device)
Classic ophthalmologic examination with visual acuity measurement and slit lamp examination of both eyes and eyelids. Then, meibographic and interferometric evaluation of his two inferior eyelids with the Lipiview device.
Sponsors
Fondation Ophtalmologique Adolphe de Rothschild
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
2 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
* Recruited from a specialized ophthalmologic consultation Rothschild Ophthalmologic Foundation, Paris, France. * Cases : suffering from ocular or oculo-cutaneous rosacea * Witnesses : without any present or past palpebral or meibomian disease
Exclusion criteria
* Unable to achieve the meibographic and interferometric examination (Lipiview)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of abortive blinks | Day of inclusion | Number of abortive blinks during the Lipiview exam |
| Clinical severity | Day of inclusion | Clinical severity is determined with a composite score, by the presence of chalazia, corneal lesions, neovascularization, phlyctena, loss of vision, superficial keratitis, anterior and posterior keratitis, meibomitis, palpebral margin keratinization, lagophthalmos, long term use of azithromycin treatment, treatment by ciclosporin eyedrops, intense cutaneous or ocular symptoms, long time evolution of the disease. |
| Meibographic severity | Day of inclusion | The meibographic severity is determined by the level of Meibomian gland atrophy, data obtained with the Lipiview |
| Interferometric severity | Day of inclusion | The interferometric severity is evaluated by the thickness of the lipid layer tear film, data obtained with the Lipiview |
Countries
France
Outcome results
None listed