Fine and Gross Motor Function and Relationship With Muscle Tone in Older Adults With and Without Dementia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03479567

Enrollment

122

Registered

2018-03-27

Start date

2015-01-31

Completion date

2017-12-31

Last updated

2023-12-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Balance, Dementia, Fine Motor Function, Gait, Muscle Tone, Paratonia

Brief summary

The purpose of this study was (1) to investigate changes in gait, balance, fine motor function, and muscle tone, and (2) to find out if there is a correlation between muscle tone/presence of paratonia and motor function (gross and fine) in mild and moderate dementia.Three groups of participants were included in the study: healthy elderly (n=60), participants with mild dementia (n=31) and participants with moderate dementia (n=31). Measurements of fine motor function, balance, gait, presence of paratonia and muscle tone measurements were performed.

Interventions

OTHERFine motor skill test

assessment of fine motor skills with Purdue Pegboard, with dominant hand, non-dominant hand and bimanual

DIAGNOSTIC_TESTParatonia Assessment Instrument (PAI)

diagnosis of paratonia based on passive movement of the four limbs

OTHERmyotonometric measurement of muscle tone

MyotonPRO measurement of muscle tone

OTHERGait accelerometry

accelerometric assessment of gait (Dynaport Hybrid): 7m walk in 3 conditions (normal pace, fast, double task)

OTHERbalance accelerometry

accelerometric assessment of balance (Dynaport Hybrid) during 10 seconds trial in 3 conditions (side-by-side, semitandem, tandem)

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

NONE

Intervention model description

cross-sectional

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* age \>= 65 years * walk independently for at least 11 meters * HC: no cognitive deterioration, MiD: dementia, Global Deterioration Scale\<5, MoD: dementia, Global Deterioration Scale 5 or 6

Exclusion criteria

* recent (≤ 6 months) orthopedic surgery

Design outcomes

Primary

Measure	Time frame	Description
MyotonPRO measurement of muscle tone	through study completion, an average of 3 years	MyotonPRO measurement
Fine motor function	through study completion, an average of 3 years	score on the Purdue pegboard test, maximal amount of (pairs of) pegs placed in 30 seconds (max. 25)
presence of paratonia	through study completion, an average of 3 years	Paratonia Assessment Instrument, resistance against passive movements of the four limbs is evaluated (Hobbelen 2008)
walking speed	through study completion, an average of 3 years	gait speed parameter
step regularity	through study completion, an average of 3 years	gait parameter representing regularity, autocorrelation (method Moe-Nilssen 2004), value between 0 and 1, with 1 representing perfect regularity
mediolateral jerk	through study completion, an average of 3 years	balance smoothness and coordination, lower jerk values correspond with better smoothness of balance
anteroposterior jerk	through study completion, an average of 3 years	balance smoothness and coordination, lower jerk values correspond with better smoothness of balance

Secondary

Measure	Time frame	Description
MyotonPRO measurement of elasticity	through study completion, an average of 3 years	MyotonPRO measurement
MyotonPRO measurement of mechanical stiffness	through study completion, an average of 3 years	MyotonPRO measurement

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026