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The Genetics of Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis, a Disease Initiated by Mucociliary Dysfunction

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03478553
Enrollment
1000
Registered
2018-03-27
Start date
2018-01-18
Completion date
2026-12-31
Last updated
2025-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Idiopathic Pulmonary Fibrosis (IPF)

Brief summary

This study seeks to screen first degree family members of people with Idiopathic Pulmonary Fibrosis (IPF) for the earliest signs of lung fibrosis.

Detailed description

The purpose of this study is to explore genetic factors associated with the development of pulmonary fibrosis. The investigators aim is to identify and explore genetic loci that affect development of pulmonary fibrosis and also explore related environmental exposures. Idiopathic pulmonary fibrosis (IPF) is one of the interstitial lung diseases under the broader umbrella of idiopathic interstitial pneumonias (IIP). The investigators hypothesize that inherited genetic factors are associated with pulmonary fibrosis. To investigate the genetics of pulmonary fibrosis, the investigators plan to enroll individuals with pulmonary fibrosis and their family members.

Interventions

OTHERBlood draw

Blood draw

OTHERQuestionnaire

Pulmonary Fibrosis Questionnaire

Sponsors

University of Colorado, Denver
Lead SponsorOTHER

Study design

Observational model
FAMILY_BASED
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Age at least 18 years old * Family member diagnosed with IPF

Exclusion criteria

\- No family member with IPF

Design outcomes

Primary

MeasureTime frameDescription
Identify and explore genetic loci and related environmental exposures in individuals with familial pulmonary fibrosis and their relatives.BaselineThe investigators aim is to identify and explore genetic loci that affect development of pulmonary fibrosis and also explore related environmental exposures. Idiopathic pulmonary fibrosis (IPF) is one of the interstitial lung diseases under the broader umbrella of idiopathic interstitial pneumonias (IIP). The investigators hypothesize that inherited genetic factors are associated with pulmonary fibrosis.

Countries

United States

Contacts

Primary ContactRachel Warren
rachel.warren@cuanschutz.edu303-724-8569

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026