Cognitive Impairment, Progressive Supranuclear Palsy
Conditions
Brief summary
The aim of this study is to better understand the nature of the cognitive decline in Progressive Supranuclear Palsy, the time of its development and the relation with the other cardinal features of the disease.
Detailed description
Progressive Supranuclear Palsy (PSP) is a neurodegenerative disease characterized by vertical supranuclear gaze palsy, early balance dysfunction and falls. Tau-protein aggregation, mainly in the brainstem, is the disease hallmark. Because of the similarities with Parkinson's disease (PD), the diagnosis is made approximately 4 years after the symptoms onset. Cognitive deficits are a leading feature of PSP and they actually represent one of the four functional core domains in the revised diagnostic criteria. The aim of this study is to better understand the nature of this cognitive decline, the time of its development and the relation with the other cardinal features of the disease.
Interventions
BEHAVIORALCognitive evaluation
An extensive battery of neuropsychological and motor tests was assessed: MMSE, FAB, MoCA, WCST, Stroop Test, TMT-A and B, Verbal fluency Test, ROCF copy and delayed recall, RAVLT, 6MWT, TUG, BBS.
Sponsors
Ospedale Generale Di Zona Moriggia-Pelascini
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Inclusion criteria
* Patients fulfilling the criteria for idiopathic PD * Patients fulfilling the criteria for PSP
Exclusion criteria
* Any other neurodegenerative disorders or medical conditions different from PD / PSP
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| RAVLT | 1 year | Rey Auditory Verbal Learning Test |
| TMT-A and B | 1 year | Trail Making Test Parts A & B |
| VFT | 1 year | Verbal fluency Test |
| ROCF copy and delayed recall | 1 year | Rey-Osterrieth complex figure test copy and delayed recall |
| MMSE | 1 year | Mini-Mental State Examination |
| FAB | 1 year | Frontal Assessment Battery |
| MoCA | 1 year | Montreal Cognitive Assessment |
| WCST | 1 year | Wisconsin Card Sorting Test |
| ST | 1 year | Stroop Test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| TUG | 1 year | Timed Up and Go Test |
| BBS | 1 year | Berg Balance Scale |
| 6MWT | 1 year | 6 Minute Walk Test |
Outcome results
None listed