Prevention of Postoperative Ileus
Conditions
Keywords
Postoperative ileus, mosapride, mouth dissolving tablets, Intraoperative vomiting
Brief summary
Giving women one day before and immediately after cesarean section a mouthly dissolving mosapride tablets 2every every 8 hours for maximum of 5 days ,or getting recovered gastrointestinal functions And assess preoperative gastrointestinal functions
Detailed description
Uncomplicated post cesarean women one day before and immediately after elective cesarean receive 2 mouthly dissolving mosapride tablets every 8 hours maximum for 5 days and clinical care giver follow the woman's gastrointestinal functions, including intraoperative and postoperative nausea vomiting, passing flatus, hearing intestinal sounds, passing stools, occurring of paralytic ileus, length of the hospital stay
Interventions
DRUGMosapride
Intake mouthly dissolving mosapride tablets in immediate post cesarean section
DRUGPlacebo Oral Tablet
Dummy identical tablets to mouthly dissolving mosapride tablets
Sponsors
Benha University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Masking description
Color coded active tablets backed in red while identical dummy tablets coded in blue,both tablets are physically identical and usually no anticipated noticed side effects from mosapride
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* all women undergoing elective cesarean section
Exclusion criteria
* prior abdominal surgery, abdominal adhesion, chronic constipation, allergy to mosapride
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time of first flatus | 96 hours postoperative | Clinical |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Paralytic ileus incidence and its severity | 7days | Clinical |
| Toleration of fluids and solids intake | 2 weeks postoperative | Clinical |
| Incidence of intraoperative and postoperative nausea and vomiting | Intraoperative and 2 weeks postoperative | Clinical |
| First defecation | 2 weeks postoperative | Clinical |
Countries
Egypt
Outcome results
None listed