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Serum and Semen Vitamin D Level With Semen Parameters

Correlation of Serum and Semen Vitamin D Level With Semen Parameters in Males

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03477136
Enrollment
150
Registered
2018-03-26
Start date
2018-12-06
Completion date
2021-04-30
Last updated
2020-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitamin D Deficiency

Brief summary

vitamin D may have multiple functions, one of them is modulating reproductive processes and the reproductive role of vitamin D is highlighted by expression of the vitamin D receptors in testis, male reproductive tract and sperms

Detailed description

Semen analysis is the corner stone of infertility evaluation as it provides information on the functional status of the seminiferous tubules, epididymis and accessory sex glands. The methods on how the semen should be evaluated are provided by the World Health Organization Vitamin D is synthesized mainly in the skin, where ultraviolet ray B radiation converts 7-dehydrocholesterol to Vitamin D3. Then, Vitamin D3 undergoes two hydroxylation processes first in the liver and second in the kidney Serum 25(OH)D is the major circulating metabolite of vitamin D and reflects vitamin D inputs from cutaneous synthesis and dietary intake. The serum 25(OH)D level is the standard clinical measure of vitamin D status Vitamin D deficiency has been linked to various health disorders including boneheallth, cardiovascular, infectious, oncologic, musculoskeletal, neuropsychologic and reproductive disorders, as well as to overall mortality

Interventions

DIAGNOSTIC_TESTELISA to evaluate serum and seminal vitamin D level

Serum and semen samples will be collected from all participant males and ELISA method used to evaluate the level of vitamin D in serum and semen

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
MALE
Age
20 Years to 50 Years
Healthy volunteers
No

Inclusion criteria

* -males with different semen parameter finding * Age: 20-50 years

Exclusion criteria

1. Varicocele. 2. Genital tract infections. 3. Primary and secondary hypogonadism 4. Hormonal therapy. 5. Calcium and vitamin D supplement. 6. Hepatic or renal failure 7. Diseases or drugs affecting vitamin D absorption -

Design outcomes

Primary

MeasureTime frameDescription
correlation of serum and semen vitamin D level with semen parameters in malesA yearevaluation the level of vitamin D in serum and semen by using ELISA method and correlate it with semen parameters

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026