Attention Disturbances, Parkinson Disease
Conditions
Brief summary
The researchers aimed to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with Parkinson's disease (PD).
Detailed description
To bypass the impaired habitual motor-behavioural control, Parkinson's disease (PD) patients may exploit the network of goal-directed mode of action. The frontostriatal connections underline this functioning, that is based on attention. Since the cognitive processes are related with dopamine, the asymmetrical degeneration of the dopaminergic system affects differently the right side affected (RPD) and the left side affected (LPD) PD patients. The aim of the study was to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with PD.
Interventions
OTHERMIRT
4-week multidisciplinary intensive rehabilitation treatment
Sponsors
Ospedale Generale Di Zona Moriggia-Pelascini
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Stage 2.5-3 according to the Hoehn and Yahr scale (H&Y); * Stable pharmacological treatment for the last 6 weeks before the enrolment and during the hospitalization; * Mini Mental State Examination (MMSE) ≥ 24; * No evidences of dysexecutive syndrome.
Exclusion criteria
* Any focal brain lesion detected in brain imaging studies (CT or MRI) performed in the previous 12 months; * Drug-induced dyskinesias; * Disturbing resting and/or action tremor, corresponding to scores 2-4 in the specific items of UPDRS III; * Behavioral disturbances (evaluated with Neuropsychiatric Inventory); * Visual and auditory dysfunctions according to the general clinical evaluation and medical history; * Equivocal report about the side of disease onset or bilateral motor involvement.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual Reaction Times (V RTs) | 4 weeks | Visual Reaction Times |
| Auditory Reaction Times (A RTs) | 4 weeks | Auditory Reaction Times |
| Multiple Choices RTs (MC RTs) | 4 weeks | Multiple Choices RTs |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Unified Parkinson's Disease Rating Scale (UPDRS) | 4 weeks | Unified Parkinson's Disease Rating Scale |
| Timed Up and Go Test (TUG) | 4 weeks | Timed Up and Go Test |
Outcome results
None listed