Microcirculation in Pregnancy
Conditions
Keywords
pregnancy, microcirculation
Brief summary
Sublingual microcirculation change in pregnant women with or without high risk pregnancy factors during pregnancy and postpartum period.
Detailed description
Microcirculation system is composed of a group of blood vessels less than 100 um in diameter composed of arterioles, capillaries, veins and other structures. The health of microcirculation system correlates well with the stability of systemic circulation. Perfusio of microcirculation is often affected by major diseases such as sepsis, shock and heart disease. Through various microcirculation monitoring instruments, the investigators can assess the disease severity and prognosis. Physiological changes during pregnancy will increase the blood volume, stroke volume, and microcirculation. Preeclampsia refers to the development of hypertension (systolic blood pressure\> 140 mmHg, diastolic blood pressure\> 90 mmHg) after 20 weeks of gestation with proteinuria. Severe preeclampsia is associated with impaired endothelial cell circulation throughout the body, and reduced sublingual microcirculation perfusion. Through the sublingual microcirculation monitor, studies have shown that pregnant women have more microcirculation perfusion than non-pregnant women, while women with severe preeclampsia and those with HELLP syndrome have impaired microcirculation. This study aims to investigate whether there is any change in the sublingual microcirculation before and after labor in healthy pregnant women and high-risk pregnant women (such as epilepsy, gestational diabetes, etc.) through the third generation of microcirculation imaging microscope (cytocam).
Interventions
None listed
Sponsors
National Taiwan University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Healthy pregnant women older than 20 years old who will delivery baby in our hospital (both normal spontaneous delivery and cesarean section). * Women over 20 years of age who will delivery baby in our hospital (both normal spontaneous delivery and cesarean section) and meet the definition of high-risk pregnancy such as gestational diabetes mellitus, placenta previa, placenta accreta, gestational hypertension, preeclampsia or severe preeclampsia.
Exclusion criteria
* Chronic hypertension or diabetes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of perfused vessel density | From the day before delivery to three days after delivery | Changes of perfused vessel density before and after delivery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes of microvascular flow index | From the day before delivery to three days after delivery | Changes of microvascular flow index before and after delivery |
| Changes of heterogeneity index before | From the day before delivery to three days after delivery | Changes of heterogeneity index before and after delivery |
Countries
Taiwan
Contacts
Primary ContactYiShiuan Lin
Outcome results
None listed