The Usage of High-resolution Magnetic Resonance Imaging in Patients With Post-stroke Aphasia for Predicting the Outcome

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03475745

Enrollment

Registered

2018-03-23

Start date

2017-11-20

Completion date

2020-06-30

Last updated

2018-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aphasia

Keywords

resting-state, DTI, aphasia, stroke

Brief summary

Combined analysis of functional and structural language network changes may be a good model for predicting language outcome.

Detailed description

Background & objectives: Language impairment after aphasic stroke is both common and debilitating. However the mechanisms of language recovery after aphasic stroke is not fully understood. Investigators plan to detect the changes of functional and structural language networks after aphasic stroke by high-resolution MRI.Then Combined analyse functional and structural language network changes, establishing a prediction model for language outcome. Methods: The proposed study is a observational trial that will include 50 patients diagnosed with post stroke aphasia from the neurology clinics at The First Affiliated Hospital, Zhejiang University. Aphasia battery of Chinese(ABC) and functional magnetic resonance imaging (MRI) will be performed at acute(\ 2weeks),subacute(3 months) and chronic phase(6months). Only routine drug therapy will be used. Relevance: Currently there is little known about the recovery mechanisms of post-stroke aphasia.The proposed study intends to analyse functional and structural language network changes by high resolution MRI, which may reveal the potential recovery mechanism underlying post stroke aphasia..

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy right-handed native Chinese speakers with more than 6-year education are recruited as healthy controls.

Exclusion criteria

* Not right-handed; * Any use of psychoactive drugs; * Less than 6-year education; * Not suitable for MRI scan.

Design outcomes

Primary

Measure	Time frame	Description
Resting state functional connectivity changes	3 months	The study uses resting state functional MRI(rs-fMRI) to measure changes of functional connectivity across regions after a spontaneous recovery.

Secondary

Measure	Time frame	Description
Aphasia Battery of Chinese, ABC	3 months	ABC, the Chinese standardized adaptation of the Western Aphasia Battery, indicates the patient's ability of spontaneous speech, auditory comprehension, repetition, naming, reading, writing.
White matter Integrity	3 months	The study uses Diffusion tensor imaging and tracking (DTI) to measure changes of the Integrity of white matter after a spontaneous recovery.
Brain response change	3 months	The study uses task functional MRI (fMRI) to measure the brain response changes during the task after a spontaneous recovery.
Resting state functional connectivity changes	6 months	The study uses resting state functional MRI(rs-fMRI) to measure changes of functional connectivity across regions after a spontaneous recovery.

Countries

China

Outcome results