The Effect of Midazolam Premedication on Copeptine Concentration in Blood

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03474939

Enrollment

Registered

2018-03-23

Start date

2017-04-03

Completion date

2019-03-01

Last updated

2019-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Copeptin, Preanesthetic Medication

Brief summary

The study aim is to assess whether premedication with midazolam prior to surgery affects copeptin concentration in blood.

Interventions

DRUGMidazolam Oral Tablet

Midazolam Oral tablet

OTHERPlacebo Oral Tablet

Glucose 1000mg tablet night before surgery and 60 minutes before surgery

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients scheduled for elective surgery * Patients with no chronić illness and considered ASA 1 by anesthesiologist * Patients with mild and controlled chronic illness considered ASA 2 by anesthesiologist

Exclusion criteria

* Patient refusal * Chronic illness requiring intense treatment or uncontrolled illness (ASA 3 or more)

Design outcomes

Primary

Measure	Time frame	Description
Change in copeptin concentration	48 hours	Change in the concentration of copeptine measured in blood serum

Countries

Poland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026