Diminished Ovarian Reserve, Ovarian Dysgenesis, Premature Ovarian Failure, Primary Ovarian Insufficiency
Conditions
Keywords
Genetic causes, etiology, POI, DOR
Brief summary
genetic screening and etiological analysis was conducted on patients with ovarian insufficiency and decline in ovarian reserve. All patients were enrolled in the IVF-treated and non-IVF-treated groups, followed up for long-term treatment outcomes and genomic screening.
Detailed description
The cause of ovarian insufficiency and decline in ovarian reserve are not clear, but most researchers think the probable causes are mainly three aspects: chromosomal abnormalities, genetic factors and autoimmune diseases，But the majority of patients with normal chromosome karyotype analysis. The screening of pathogenic genes in patients with normal karyotype is the focus of current premature ovarian insufficiency(POI) and decline in ovarian reserve(DOR) etiology, to further explain the pathogenesis of patients, improve the diagnosis of those diseases and Clinical treatment.
Interventions
PROCEDUREIVF treatment
Relationship between IVF treatment outcome and genotypes in POI//DOR/ovarian dysgenesis patients
Sponsors
National Research Institute for Family Planning, China
The First Affiliated Hospital of Anhui Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed as premature ovarian insufficiency, diminished ovarian reserve, primary amenorrhea, ovarian dysgenesis, repeated implantation failure
Exclusion criteria
* To rule out polycystic ovary syndrome（PCOS）, iatrogenic factors (such as surgery, radiotherapy and chemotherapy, etc.) lead to premature ovarian insufficiency in patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Genotype | 1/4/2018-24/12/2020 | Measure the genotype by genome-wide sequencing of exomes(WES) in subjects. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dimensions of uterus | 1/4/2018-24/12/2020 | Measure the vertical diameter，transverse diameter and anteroposterior diameter of uterus in millimeters |
| Antral follicle count | 1/4/2018-24/12/2020 | Measure the basic antral follicle count before controlled ovarian hyperstimulation. |
| Endometrial thickness | 1/4/2018-24/12/2020 | Measure endometrial thickness of subjects in millimeters. |
| Live birth rate | 1/4/2018-24/12/2020 | Record the live birth rate of offspring in in both groups. |
| Neonatal weight | 1/4/2018-24/12/2020 | Record the neonatal weight(in kilogram) of offspring in two groups. |
Countries
China
Contacts
Primary ContactYiran Zhou, bachelor
Backup ContactBinbin Wang, PhD
Outcome results
None listed