Ovarian Hyperstimulation
Conditions
Keywords
Calcium infusion, Cabergoline
Brief summary
Giving oral Cabergoline or calcium infusion in women at high risk for developing ovarian hyperstimulation syndrome in context of assisted reproductive technologies aiming in its prevention
Detailed description
Women undergoing in vitro fertilization or intracytoplasmic sperm injection whom were at high risk for developing ovarian hyperstimuation syndrome were received either oral Cabergoline.5mg tablets for 7days starting on ovum pick up day and continued for 7days or received 10ml of 10%calcium gluconate in 200ml normal saline on ovum pick up day and continued for 4days
Interventions
DRUGOral Cabergoline
Giving oral Cabergoline tablet 0.5 milligram daily starting on ovum pick up day and continued for seven days
Giving 10 ml of 10 % calcium gluconate on 200 ml normal saline solution o.9% intravenously over thirty minutes starting on ovum pick up day and continued for four days
Sponsors
Benha University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* women undergoing assisted reproductive technologies whom at high risk for developing ovarian hyperstimulation syndrome as with high basal antimullerian hormone ,excess antral follicular count ,high seum estradiol on day of humian choronic gonadotrophin
Exclusion criteria
women with other endocrinopathy as congenital adrenal hyperplasia , hyperprolactinemia,diabetes \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Occurrence of ovarian hyperstimuation syndrome | 20 days from ovum pick up day | Clinical condition occurred in context of assisted reproductive technologies in which there serous sacs fluid accumulation and hemoconcentration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Types of ovarian hyperstimuation syndrome and severity | 20 days from ovum pick up day | Clinical severity either mild ,moderate or severe and its type either early or late onst |
| Chemical pregnancy | 14 day from embryos transfer day | Positive human chorionic Gonadotropin in blood |
| Clinical pregnancy | 5 week from embryos transfer day | Intrauterine gestational sac |
Countries
Egypt
Outcome results
None listed