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Endodontic Medications for Irreversible Pulpitis: Articaine or Eugenol?

Articaine or Eugenol: a Study on the Choice of Endodontic Medication in the Emergency Management of Irreversible Pulpitis of a Mature Permanent Tooth

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03472456
Enrollment
100
Registered
2018-03-21
Start date
2018-03-22
Completion date
2019-10-24
Last updated
2020-09-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endodontic Inflammation, Operative Dentistry, Pulpitides, Toothaches

Brief summary

The objective of the study is to determine which of the two commonly used endodontic medications (Eugenol VS Articaine) is most effective in controlling postoperative pain in irreversible pulpitis of the mature permanent tooth in adults. To do so, an assessment of the pain felt by patients will be carried out a few days apart. The supposed results are that the medications are equivalent in terms of effectiveness on the pain, but could then present different economic arguments

Detailed description

In irreversible pulpitis of the mature permanent tooth, the enrolled patients receive endodontic medications (Eugenol or Articaine) in order to determine which one is the more efficient to control the pain. These patients would have received the same medication without this study. That's why this is an obsevationnal study.

Interventions

DRUGImplementation of a pulp medication in compliance with the dental emergency management protocol: articaïne

Implementation of a pulp medication in compliance with the dental emergency management protocol: articaïne

DRUGImplementation of a pulp medication in compliance with the dental emergency management protocol: eugenol

Implementation of a pulp medication in compliance with the dental emergency management protocol: eugenol

Sponsors

University Hospital, Strasbourg, France
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Adult patient, major, affiliated to a social health insurance scheme * Patient having agreed to participate in the study * Urgent consultant patient for irreversible pulpitis * Patient understanding French

Exclusion criteria

* Refusal of the patient to participate in the study * Impossibility of performing the surgical procedure * Impossibility to give the subject information enlightened (difficulty of understanding ...) * Subject under the protection of justice, or under guardianship * General contraindication to endodontic treatment in 2 sessions (high risk of infectious endocarditis, for example) * Chronic intake of analgesic drugs

Design outcomes

Primary

MeasureTime frameDescription
Pain evolution (decrease or increase the intensity of the pain)7 daysEvolution of pain (using a score of 0 to 10)

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026