Measurement of the Cervix During Pregnancy According to Age of Conization

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03472066

Acronym

MesCon

Enrollment

Registered

2018-03-21

Start date

2018-10-04

Completion date

2022-04-13

Last updated

2026-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervix; Pregnancy

Brief summary

Treatment of precancerous lesions of the cervix by conization has been shown to increase the risk of premature delivery and premature rupture of the membranes. It has now been clearly established that the cervix is a growing organ during adolescence and early adulthood, It has been hypothetized that cervical conization during the growth phase reduced its growth potential, and induced shorter cervix during the upcoming pregnancy. No studies have been conducted investigating the age at which conization no longer had an impact on cervical size during pregnancy. This will help to identify the age at conisation below which patients will be identified as being at risk event, and thus offer increased monitoring and possibly prophylactic management by programmed strapping. We propose to measure the length of the cervix of pregnant patients who have benefited from conization, which is currently recommended by the Collège National des Gynécologues Obstetriciens Français .In addition, the investigators will use a control group consisting of non-con conical, parity-matched pregnant patients in whom a cervical measurement will also be performed.

Interventions

OTHERPrevious conization

a group of women who have been conized,

OTHERno previous conization

group with asymptomatic patients on routine second trimester echography

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Patient referred since January 2008 with pregnancy between 2008 and 2017 2. Pregnancy after conisation 3. Cervix size between 21 and 24 SA before any obstetric event 4. Control group: parity matching, asymptomatic patients

Exclusion criteria

1. Threat of late miscarriage, 2. Premature rupture of membranes before cervical echography, 3. Other pregnancies after study of 1st pregnancy after conisation, 4. No measurement of the conization specimen, 5. Lost to follow-up, 6. Age \<18 7. Twin Pregnancies 8. Patient under guardianship

Design outcomes

Primary

Measure	Time frame	Description
The main objective is to study the correlation between the size of the cervix and the age at conization. age at conization	1 day	Cervix length Measured during the second semester echography

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 13, 2026