Breast Cancer, Radiation Toxicity
Conditions
Keywords
breast cancer, radiotherapy, cutaneous toxicity, subcutaneous toxicity, local control, IMRT
Brief summary
To assess feasibility of postoperative IMRT with concomitant boost in moderate-high risk breast cancer in terms of late toxicity and local control
Detailed description
Patients treated conservatively with moderate-high risk breast cancer were treated with IMRT plus concomitant boost to surgical bed (up to a dose of 50 Gy to whole breast and 60 Gy to the tumor bed). Aim of the study was to evaluate late toxicity and local control after this treatment compared with a historical control group (CG) of patients treated with 3D-conformal postoperative radiotherapy delivered with conventional fractionation.
Interventions
RADIATIONIMRT with concomitant boost
RADIATION3D-RT with sequential boost
Sponsors
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* histologically confirmed invasive breast cancer (pT1-4) with at least one of these characteristics: 3 or more metastatic axillary nodes, pre or peri-menopausal status, close resection margins * breast conservative surgery
Exclusion criteria
* positive margins * distant metastases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of treatment.related late adverse events | 5 years | late toxicity (cutaneous and subcutaneous) is evaluated using RTOG/EORTC criteria in both groups of patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Local control | 5 years | absence of locoregional relapse |
Outcome results
None listed