Study of the Correlation Between Muscle Oxygenation and Motor Function in Children With Neuromuscular Disease.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03471676

Acronym

OXMNM

Enrollment

Registered

2018-03-20

Start date

2018-03-26

Completion date

2019-05-28

Last updated

2021-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuromuscular Diseases in Children, Neuromuscular Diseases in Infants

Brief summary

Preliminary data underline the fact that muscular deoxygenation during training happens earlier in adult patients suffering from neuromuscular disorders in comparison to controls. Up to date, pediatric data are lacking. The study aims at demonstrating if a correlation exists between the motor deficiency and the muscular deoxygenation in children suffering from neuromuscular disorders.

Detailed description

Preliminary data underline the fact that muscular deoxygenation during training happens earlier in adult patients suffering from neuromuscular disorders in comparison to controls, as it was demonstrated in Becker muscular dystrophy patients and fascioscapulo humeral muscular dystrophy. Moreover, the deoxygenation kinetics was positively correlated to the functional status and the muscular deficiency severity. However, no pediatric study has been conducted on this topic up to date. The aim of the study is to determine if a correlation exists in children suffering from neuromuscular diseases: * between muscular oxygenation and the percentage of the 6 minutes walking test performed in the routine medical care * between muscular oxygenation and the total and D1 motor function measure value

Interventions

OTHERMuscular oximetry

6 minutes walking test performed in the routine medical care with muscle oximetry recording

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Years to 17 Years

Healthy volunteers

Inclusion criteria

* Children from 6 to 18 years-old suffering from a neuromuscular disorder * Able to walk, with or without help

Exclusion criteria

* Hypoxia secondary to heart or lung disease * Visual impairment (\<5/10) * Parents refusal concerning data storage

Design outcomes

Primary

Measure	Time frame	Description
Muscular oxygenation	6 minutes	Muscular oximetry

Secondary

Measure	Time frame	Description
6 minutes walking distance	6 minutes	6 minutes walking distance
Motor function	25 minutes	Motor function measure (MFM scale)

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026