CMR Features in Patients With Suspected Myocarditis

Conditions

Outcome, Fatal

Brief summary

Presentation of myocarditis is heterogeneous, often ranges from being asymptomatic, to chest pain, dyspnoea, palpitations, and even sudden cardiac death. Diagnosing myocarditis is challenging with no current uniform clinical gold-standard. CMR is a key investigative tool, however the predictive value of CMR features is unknown. In this study we assess 670 consecutive patients with suspected myocarditis who were referred for CMR between 2002 and 2015 at the BWH. CMR features such as late gadolinium sizing, T1 mapping, extracellular volume fraction assessment, strain analysis (feature tracking), clinical data, labortory tetsings and electrocardiogramm are linked to the outcome in order to assess its predictive value.

Bernhard B, Schnyder A, Garachemani D, Fischer K, Tanner G, Safarkhanlo Y, Stark AW, Schütze J, Pavlicek-Bahlo M, Greulich S, Johner C, Wahl A, Benz DC, Kwong RY, Gräni C.

2022-10-1918 citations

10.1016/j.jcmg.2022.08.011

Reproducibility and its confounders of CMR feature tracking myocardial strain analysis in patients with suspected myocarditis

Kady Fischer, Olivier L. Linder, Sophie A. Erne, Anselm W. Stark, Sarah J. Obrist et al. (10 authors)

European Radiology2021-12-2134 citations

10.1007/s00330-021-08416-5

Feature Tracking Myocardial Strain Incrementally Improves Prognostication in Myocarditis Beyond Traditional CMR Imaging Features.

Fischer K, Obrist SJ, Erne SA, Stark AW, Marggraf M, Kaneko K, Guensch DP, Huber AT, Greulich S, Aghayev A, Steigner M, Blankstein R, Kwong RY, Gräni C.

2020-07-15109 citations

10.1016/j.jcmg.2020.04.025

Comparison of myocardial fibrosis quantification methods by cardiovascular magnetic resonance imaging for risk stratification of patients with suspected myocarditis

Christoph Gräni, Christian Eichhorn, Loïc Bière, Kyoichi Kaneko, Venkatesh L. Murthy et al. (11 authors)

Journal of Cardiovascular Magnetic Resonance2019-01-01111 citations

10.1186/s12968-019-0520-0

Interventions

DIAGNOSTIC_TESTCMR

Outcome analysis of CMR features in suspected myocarditis patients

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* patients referred by their treating physician to undergo CMR for suspected myocarditis as the primary clinical question

Exclusion criteria

* evidence of coronary artery disease * hypertrophic cardiomyopathy * arrhythmogenic right ventricular cardiomyopathy * cardiac sarcoidosis * cardiac amyloidosis * takotsubo cardiomyopathy * constrictive pericarditis * Loeffler endocarditis * ventricular non-compaction * cardiac tumor * pulmonary embolism * severe valve disease

Design outcomes

Primary

Measure	Time frame	Description
Major adverse cardiac events	through study completion, an average of 2 years	Heart failure hospitalization; all cause death; sustained ventricular arrhythmia; recurrent myocarditis; transplantation

Countries

United States

Outcome results

None listed