Pain
Conditions
Brief summary
This study compares the the efficacy of buccal infiltration of 4% Articaine and 2% Mepivacaine without any palatal injection during extraction of maxillary teeth. One group of patient receives buccal infiltration of Articaine and another group receives buccal infiltration of Mepivacaine.
Detailed description
Dense local anesthesia is required to reduce pain during extraction of tooth. Administration of local anesthesia to the palatal mucosa is proved to be the most painful due to its firm adherence to the underlying periosteum and also it's abundant nerve supply. Articaine has greater lipid solubility and high bone penetration property. Mepivacaine is proven to be the safest local anaesthetic agent. Avoidance of a palatal injection during extraction will benefit the patient by reducing pain and anxiety to a greater extent. So this study compares the bone penetration property between Articaine and Mepivacaine by assessing the pain in the palatal mucosa while extracting the tooth using only buccal infiltration.
Interventions
DRUGbuccal infiltration of 4% Articaine with Epinephrine
Articaine Hydrochloride 4 % / Epinephrine 1:200,000 1.8 ML Cartridge
DRUGbuccal infiltration of 2% Mepivacaine with Epinephrine
Mepivacaine Hydrochloride 2% Epinephrine 1:200,000 2.2 Ml Cartridge
Sponsors
Melaka Manipal Medical College
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients aged 18 years and above * Patients requiring extraction of maxillary teeth which are grossly decayed, grade I mobile, root stumps or indicated for therapeutic extractions. * Healthy patients ( ASA I ) or patients with mild systemic disease with no functional limitations (ASA II). * Patients who are not allergic to the drugs used in the study
Exclusion criteria
* Patients with periapical infections. * Patients who are on concurrent treatment with NSAIDs and corticosteroids
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of pain intensity | 10 minutes after the administration of the drug | pain intensity in the palatal mucosa is measured using Visual Analogue Scale during instrumentation to check objective symptoms of numbness. The pain is marked from 0-100 mm in a 100 mm visual analogue scale ( 0= no pain, 100= extremely severe pain). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Response rate | Through the extraction procedure | the total number of patients with pain score more than 40 mm in visual Analogue Scale resulting in a palatal injection. |
Countries
Malaysia
Outcome results
None listed