Diabetes, Kidney Function Affection Upon Exposure to Radiocontrast, Microalbuminuria
Conditions
Brief summary
To study the effect of radiocontrast material on kidney functions in diabetics with microalbuminuria
Detailed description
Study design: This study will be an observational prospective cohort study. Study population: Diabetics undergoing any intervention using radiocontrast material for any medical indication in Fayoum universiy hospital will be selected. There will be two arms of the study,each arm will contain 20 patients first arm diabetics on linagelptin, second arm diabetics on other DPP4 inhibitors. Data collection: Patients will be subjected to; full clinical examination,waist hip ratio assessment,BMI assessment fasting blood glucose,Serum uric acid, urine ACR, eGFR will be done before and after the investigation.
Interventions
DRUGLinagliptin Oral Tablet
Linagliptin for blood glucose control
Sponsors
Boehringer Ingelheim
Fayoum University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diabetics on DPP 4 inhibitor treatment
Exclusion criteria
* Diabetics on insulin
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| affection of estimated glomerular filtration rate | Two months | A significant decrease in estimated glomerular filtration rate (eGFR) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change in serum uric acid | Two months | A significant rise in serum uric acid |
Other
| Measure | Time frame | Description |
|---|---|---|
| Affection of albumin creatinine ratio | Two months | A significant increase in albumin creatinine ratio in urine (ACR) |
Countries
Egypt
Outcome results
None listed