Acute Leukemia, Hodgkin Lymphoma, Malignant Haemopathies, Non-hodgkin Lymphoma
Conditions
Keywords
Malignant haemopathies, Acute Leukemia, Non-hodgkin Lymphoma, Hodgkin Lymphoma, Young adults, Adolescent
Brief summary
Unicentric retrospective analysis of a cohort of 602 young adult and adolescent patients, aged 15 to 30 years, with haematological malignancies, and managed between 2000 and 2016
Detailed description
The therapeutic results (response and survival) of young adult and adolescent patients with hematological malignancies are generally lower than those usually observed in adults over the age of 30, with equivalent treatment, particularly in lymphomatous pathology.The overall analysis of this large cohort of patients in its entirety, then by age groups (15-17 years, 18-25 years, 26-30 years) and pathology aims to describe the future of patients and patients. compare them to the results of the literature observed in this age group, and according to the therapeutic regimens administered (pediatric regimen or adult regimen).
Interventions
DRUGadministered therapeutic regimens
administered therapeutic regimens
Sponsors
Institut Paoli-Calmettes
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to 30 Years
Inclusion criteria
* Malignant hemopathies (acute leukemia, non-Hodgkin's lymphoma, Hodgkin's lymphoma) in primary care between 2000 and 2016.
Exclusion criteria
* Not applicable
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Global Survival | 15 years | delay between the date of diagnosis and the date of the latest news |
| Survival without event | 15 years | delay between the date of diagnosis and an event (relapse, death, lost of follow-up) |
| Progression-free survival | 15 years | defined as the delay between the date of diagnosis and the date of relapse or death. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Overall survival (OS) of patients included in clinical trials compared to patients not included for the overall cohort and pathology | 15 years | Overall survival (OS) of patients included in clinical trials compared to patients not included for the overall cohort and pathology |
| Event-free survival (EFS) of patients included in clinical trials compared to patients not included for the overall cohort and pathology | 15 years | Event-free survival (EFS) of patients included in clinical trials compared to patients not included for the overall cohort and pathology |
| Epidemiological distribution by pathology compared to the adult population over 30 years | 1 day | Epidemiological distribution by pathology compared to the adult population over 30 years |
| Long-term toxicity analysis (second cancers, fertility) for the global cohort and pathology. | 15 years | Long-term toxicity analysis (second cancers, fertility) for the global cohort and pathology. |
| Progression-free survival (PFS) of patients included in clinical trials compared to patients not included for the overall cohort and pathology | 15 years | Progression-free survival (PFS) of patients included in clinical trials compared to patients not included for the overall cohort and pathology |
| Descriptive analysis of the characteristics of the disease at diagnosis by pathology | 15 years | Descriptive analysis of the characteristics of the disease at diagnosis by pathology |
| Descriptive analysis of treatments by pathology | 15 years | Descriptive analysis of treatments by pathology |
Countries
France
Outcome results
None listed