Dyspnea, Healthy Volunteers
Conditions
Keywords
Dyspnea, High flow nasal cannula
Brief summary
To develop an experimental model of dyspnea by external thoraco-abdominal elastic strapping at rest in order to study the mechanisms involved in the relief of dyspnea by the administration of high flow by nasal cannula (HFNC).
Detailed description
This study will measure the effect of HFNC on an experimental model of dyspnea induced by thoraco-abdominal elastic strapping on healthy subjects at rest. The study will also compare the effects on dyspnea of the administration of high flow nasal cannula with and without oxygen added.
Interventions
DEVICEOptiflow with an inspired fraction of oxygen of 100%
Respiratory gaz heated and humidified system of delivery with a fraction of oxygen inspired of 100%
DEVICEOptiflow with an inspired fraction of oxygen of 21%
Respiratory gaz heated and humidified system of delivery with a fraction of oxygen inspired of 21%
Sponsors
Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers
Exclusion criteria
* chronic pathology * active smokers * anxiety disorder * allergy to latex * protected adult * woman declared herself pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effects of high flow nasal cannula on strapping induced type of dyspnea | One hour | Evaluated by visual annylogic scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Compare the effect of the high flow by nasal cannula with and without oxygen on an experimental dyspnea, evaluated by the differences of changes in the visual analogic scale | One hour | Evaluated by visual annylogic scale |
Countries
France
Outcome results
None listed