The Effect of Dexmedetomidine on Postoperative Quality of Recovery
Conditions
Brief summary
Dexmedetomidine is a selective a2-agonist and a sedative with anti-inflammatory,analgesic, and antiemetic effects, and its use for procedural sedation during endoscopy or ablation for atrial fibrillation has been increasing. It is also used for sedation in the intensive care unit. Recently, it was reported that dexmedetomidine is often used as an adjuvant for general anesthesia. Sympatholysis of dexmedetomidine can attenuate the increased sympathetic tone after surgery and result in antistress effects. In addition, opioid-sparing and analgesic effects are promoted by the perioperative administration of dexmedetomidine. Although it has been reported that the perioperative administration of dexmedetomidine improves quality of recovery after spinal and ENT surgeries, the outcomes for patients who undergo laparoscopic cholecystectomy remain poorly investigated. The aims of this study were to evaluate the effects of preoperative dexmedetomidine administration on quality of recovery by using the QoR-40 questionnaire in patients who undergo laparoscopic cholecystectomy.
Interventions
DRUGDexmedetomidine
Patients assigned in Dexmedetomidine or Placebo group are given Dexmedetomidine or normal saline after induction of anesthesia.
Sponsors
Kyungmi Kim
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* The patients who undergo elective cholecystectomy * Adults (20\ 75 years old) * an American Society of Anesthesiologists physical status of I or II
Exclusion criteria
* The patients do not provide written informed consent * The patients have had allergic response to dexmedetomidine. * The patients have mood disorder or anxiety disorder. * The patients are not able to express their emotions. * The pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quality of recovery questionnaire | postoperative first day | The Quality of Recovery questionnaire (QoR-40) is a tool used to assess the quality of recovery after surgery through questions pertaining to 40 items related to 5 domains. It has been validated as a global and reliable measurement tool. |
Countries
South Korea
Outcome results
None listed