Bariatric Surgery, Obesity, Sleeve Gastrectomy
Conditions
Keywords
Diet, Dietary Habits, Weight changes
Brief summary
The purpose of the study is to compare dietary habits after bariatric surgery in patients with poor weight loss versus good weight loss outcomes.
Detailed description
The obesity epidemic is a major public health concern with a significant economic burden in the USA. Bariatric surgery is the most effective and durable weight loss treatment, with long-term cardiometabolic health benefits. Among different types of bariatric procedures, sleeve gastrectomy (SG) has become the most commonly performed in USA. While SG is expected to result in a 50-60% excess weight loss, inter-individual differences in weight loss are large and approximately 25% of patients can be considered poor weight-loss responders who either do not lose a substantial amount of weight or regain the lost weight afterwards. The mechanisms underlying this clinical variation remain unknown and interventions to improve on these outcomes critically lacking. Of interest, altered daily dietary habits are experienced by a substantial proportion of bariatric surgery candidates, raising the question whether such alterations may contribute to inter-individual differences in weight loss success. Therefore, the purpose of the study is to compare dietary habits after bariatric surgery in patients with different weight loss outcomes.
Interventions
OTHERIn-laboratory assessment
Participants will stay in the laboratory for two days and one night during which they will complete questionnaires, have blood drawn, and have other measurements taken.
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
Brigham and Women's Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
22 Years to 62 Years
Healthy volunteers
No
Inclusion criteria
* Bariatric surgery (sleeve gastrectomy) patients
Exclusion criteria
* Insulin-dependent diabetes * Anemia * Smoking * Shift work within the past 1 year * Drug or alcohol dependency * Bipolar disorder * Post traumatic stress disorder (PTSD)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Self-rated hunger | One day of laboratory protocol | Hunger measured from the visual analogue scale (VAS) questionnaire |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Self-rated appetite | One day of laboratory protocol | Appetite measured from the visual analogue scale (VAS) questionnaire |
| Appetite-regulating hormones | One day of laboratory protocol | Appetite-regulating hormones from blood samples |
Countries
United States
Outcome results
None listed