Asthma, Chronic Obstructive Pulmonary Disease, Healthy Subjects, Interstitial Lung Disease, Upper Airway Obstruction
Conditions
Keywords
Impulse Oscillometry, Chinese, Healthy Subjects, Chronic Obstructive Pulmonary Disease, Asthma, Interstitial Lung Disease, Upper Airway Obstruction, Reference Values
Brief summary
The purpose of this study is to establish the reference values of impulse oscillometry (IOS) in healthy Chinese, and compare the indices of IOS in patients with lung disease, such as chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease (ILD), and upper airway Obstruction (UAO).
Interventions
OTHERClinical Observation
No treatment given but observation with IOS
Sponsors
Beijing Hospital
Beijing Children's Hospital
Shanghai Zhongshan Hospital
Second Affiliated Hospital, School of Medicine, Zhejiang University
West China Hospital
Tongji Hospital
Third Military Medical University
Xiangya Hospital of Central South University
People's Hospital of Anshun City of Guizhou Province
Shanghai Pulmonary Hospital, Shanghai, China
Beijing Chao Yang Hospital
Guangzhou Institute of Respiratory Disease
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
4 Years to 95 Years
Healthy volunteers
Yes
Inclusion criteria
for healthy subjects: * life-long non-smokers * no symptoms and history of chronic cardiopulmonary diseases (chronic bronchitis, asthma, lung cancer, pulmonary fibrosis, pulmonary tuberculosis, chronic heart diseases, etc.) * no abnormal findings on physical examination * written informed consent was obtained Inclusion Criteria for COPD: * Diagnosis of chronic obstructive pulmonary disease (COPD), as classified by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines and post-bronchodilator FEV1/FVC (forced vital capacity) \< 70%. Inclusion Criteria for asthma: * Diagnosis of asthma, as classified by national and international asthma guidelines. Inclusion Criteria for ILD: * ILD diagnosis confirmed by lung biopsy, X ray or BALF analysis. Inclusion Criteria for UAO: * Diagnosis of UAO.
Exclusion criteria
for healthy subjects: * upper or lower respiratory infection within 4 weeks * long-term exposure to harmful gas or particles * using β-blocker for treatment * pregnant women, epileptic * other diseases or surgeries potentially affecting lung function
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Airway resistance | one minute | The indices of Airway resistance include total respiratory impedance (Zrs). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, and maximum midexpiratory flow (MMEF). | one minute | The indices of spirometry include forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, and maximum midexpiratory flow (MMEF). |
Countries
China
Contacts
Primary ContactJinping Zheng, MD
Outcome results
None listed