Low Tidal Volume Ventilation
Conditions
Brief summary
A study of two ventilatory strategies for low tidal volume ventilation compared to a control group to elucidate if low tidal volumes of 3ml/kg or 4ml/kg were feasible for one lung ventilation.
Detailed description
This study investigated the feasibility of low tidal volume ventilation for one lung ventilation. 45 patients were recruited - 15 patients in each of three groups, 3ml/kg, 4ml/kg or usual care. Outcomes studied were length of stay, 30 day mortality, unplanned ICU admission, evidence of respiratory failure or requirement for non-invasive ventilation, chest x-ray infiltrates and requirement for antibiotics.
Interventions
PROCEDUREtidal volume ventilation
low tidal volume ventilation
Sponsors
University of Dublin, Trinity College
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Masking description
open label, randomisation blinded
Intervention model description
parallel assignment
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* ASA I-III lung resection surgery requiring one lung ventilation
Exclusion criteria
* ASA IV or above under 18 or over 80 years of age pregnancy previous lung lobectomy or pneumonectomy requirement for massive transfusion during the case BMI \> 35
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Radiological evidence of injury to the ventilated lung | post operatively up to 6 weeks post operatively | evidence of infiltrates in the non operative lung |
| unplanned ICU admission | up to 6 weeks post operatively | unplanned admission to the icu with respiratory issues |
| Requirement for non-invasive ventilation | up to 6 weeks post operatively | whether a patient in the trial requires niv for respiratory failure |
| Hospital acquired pneumonia | up to discharge at 6 weeks post operatively | pneumonia acquired in hospital |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| length of icu stay | until patient discharge at 6 weeks post operatively | number of days in ICU |
| 30 day mortality | 30 days post operatively | number of patients who died within 30 days of their procedure |
| length of hospital stay | until patient discharge at 6 weeks post operatively | number of days in hospital |
Countries
Ireland
Outcome results
None listed