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Does Salt Intake Improve Mood

Do Humans Over-consume Salt to Improve Mood

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03467568
Enrollment
120
Registered
2018-03-16
Start date
2017-01-01
Completion date
2018-04-01
Last updated
2018-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mood, Salt Intake

Keywords

Mood Salt

Brief summary

Humans display a preference for salt although the reasons remain unclear. The aim was to examine the hypothesis that salt may enhance mood. The study compares the drinking of water with and without electrolytes (either dissolved in water or by capsule). Mood was rated over a period of 155 minutes

Detailed description

Study 1. 120 young adults will be were recruited. They will arrive in the laboratory at 0900 having consumed their normal breakfast. Over the morning they will reported their mood by responding to one hundred millimetre visual analogue scales anchored with the words: Composed/Anxious; Hostile/Agreeable; Elated/Depressed; Unsure/Confident; Energetic/Tired; Confused/Clearheaded. These dimensions of mood came from the factor analysis that formed the basis of the Profile of Mood State questionnaire. An overall measure of mood will be calculated. . Randomly they will receive either a 150ml glass of water, or an equivalent volume of water containing electrolytes (in total 150mg sodium chloride and 45mg potassium chloride (Gatorade G2 Low calorie (34 kcal) Thirst Quencher, Pepsico). This drink will be consumed for a first time after 50 minutes, and a second time after 140 minutes. A estimate of habitual salt preference will be gained by responding to questions concerning the adding of salt to meals and a preference for salty foods. Study 2: One hundred and twenty young adults will be recruited. A second study attempts to replicate the first in a double-blind trial where the taste of salt was hidden by using a capsule. . Participants will be assigned to one of four experimental conditions; 1) swallowed placebo capsules; 2) swallowed capsules containing electrolyte (300mg sodium chloride); 3) received placebo capsules and plain water; 4) received capsules containing electrolyte and plain water. Each drink will be 150ml of water. The allocation of the type of capsule will be carried out double-blind, determined by computer generated random numbers. Otherwise the procedure will be identical to study one.

Interventions

DIETARY_SUPPLEMENTSodium Chloride

300mg sodium chloride will be provided in a capsule

OTHERPlacebo capsule

A capsule of identical appearance to that providing salt, but not containing electrolytes, will be consumed

DIETARY_SUPPLEMENTWater

Twice during the morning a drink of 150ml of water will be consumed

BIOLOGICALNo water consumed

No water will be consumed during the monring

Sponsors

Swansea University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)

Masking description

Salt / placebo will be consumed by capsule under a double blind procedure

Intervention model description

The study has four arms. Salt alone; salt plus water; placebo alone, placebo plus water

Eligibility

Sex/Gender
ALL
Healthy volunteers
Yes

Inclusion criteria

Self declared in good health -

Exclusion criteria

\-

Design outcomes

Primary

MeasureTime frameDescription
Mood ratings using visual analogue scalesUp to three hoursOn a hundred millimetre scale ratings will be made of with the two ends anchored with the words Agreeable/Hostile, Confused/clearheaded; composed/anxious; depressed/elated; confident/unsure; tired/energetic. Each scales produces a score between 0 and 100. When added to create a total mood score the ratings vary between zero and six hundred with a higher score indicating a better mood

Secondary

MeasureTime frameDescription
Ratings of thirstUp to three hoursRating made using a visual analogue scale responding to the question how thirsty do you feel right now? With a high score indicated greater thrist
Body weightUp to three hoursChanges in body weight over morning. Scales measuring to the nearest 10g will be used

Countries

United Kingdom

Contacts

Primary ContactDavid Benton, DSc
d.benton@swansea.ac.uk++441792295607
Backup ContactHayley Young, PhD
h.a.young@swansea.a.cuk++441792295908

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026