Elective Craniotomy-candidated Patients
Conditions
Keywords
SSI, elective Craniotomy, Vancomycin, Cefazolin, Antibiotic
Brief summary
Surgical-site infection is the most commonly reported nosocomial infection in patients undergoing surgery and 3rd most nosocomial infection in hospitalized patients. The SSI is associated with increases of length of hospitalization for 6 days and increases the hospital's cost by $ 300. Because of these, prevention of SSI with appropriate antibiotic is essential.
Interventions
DRUGVancomycin
The 1st group receives vancomycin an hour before craniotomy
DRUGCefazolin
The 2nd group receives cefazolin an hour before craniotomy
Sponsors
Isfahan University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age 18 years and above * elective surgical patients * No pre-surgery infection * Do not use antibiotics before surgery * Insensitivity to beta-lactam antibiotics
Exclusion criteria
* cranioplasty * Failure to follow the patient * The patient's unwillingness to continue participating in the research project * Death of the patient
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| infection rate | Until 90 days after admission | compare of infection rate in 2 groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| raise of ESR & CRP | Until 90 days after admission | compare the raise of ESR & CRP in 2 groups |
| length of hospitalization | Until 90 days after admission | compare the length of hospitalization in 2 groups |
Countries
Iran
Contacts
Primary ContactRasool Mohammadi, Student
Outcome results
None listed