Shock
Conditions
Keywords
Lactic Acid
Brief summary
During shock, arterial hypotension, inadequate cardiac output and microcirculatory alterations lead to tissue hypoxia, multiple organ failure and death. Arterial lactate is considered as the best marker of tissue hypoxia. A lactate decrease during the first 6 hour is strongly associated with better outcome and may be used as a target for assessing the efficiency of shock resuscitation. The EIRUS system (Maquet Critical Care AB, 17154, Solna, Sweden) is a new device allowing the continuous measurement of venous lactate through a central venous catheter. However, before being used extensively, such device needs to be evaluated concerning its accuracy. The aim of the present study is to assess the reliability of this device.
Interventions
DEVICEEIRUS system (Maquet Critical Care AB, 17154, Solna, Sweden)
continuous measurement of venous lactate through a central venous catheter by microdialysis
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
Acute circulatory failure defined as : systolic blood pressure\<90mmHg or mean arterial pressure \<65mmHg and blood lactate \> 2mmol/L
Exclusion criteria
Pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Agreement | Every 4hours for 48hours | Agreement between sequential arterial blood lactate measurement and continuous venous lactate obtained by microdialysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Interchangeability | Every 4hours for 48hours | Interchangeability of the variations of the two methods using the trend interchangeability method |
Countries
France
Outcome results
None listed