Cardiac Arrest, Out-Of-Hospital
Conditions
Brief summary
The study is aimed to assess (a) the incidence of hyperoxia at the point of return of spontaneous circulation (ROSC) and (b) the role of arterial blood oxygen partial pressure to brain oxygenation during out-of-hospital cardiac arrest. 80 adult patients will be recruited in a physician staffed helicopter emergency medical services. Brain regional oxygen saturation and invasive blood pressure are monitored until hospital admission and arterial blood gases are analyzed immediately when the unit arrives to the patient and again at the time of ROSC.
Interventions
OTHERStandard cardiopulmonary resuscitation
Standard Advanced Life Support based on guidelines 2015, including mechanical chest compression device
Sponsors
Helsinki University Central Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* out-of-hospital cardiac arrest of presumed cardiac origin * resuscitation will be continued at least 5 minutes (if return of spontaneous circulation not achieved earlier) after arrival of physician team
Exclusion criteria
* do-not-attempt-resuscitation (DNAR) order or withdrawal of treatment by prehospital critical care physician * return of spontaneous circulation achieved before physician-led critical team arrives * external cause for cardiac arrest (e.g. trauma, suffocation) * workload too high or environment too dangerous to perform study procedures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Arterial oxygen partial pressure | 5-60 minutes | Arterial oxygen partial pressure at the time of return of spontaneous circulation (ROSC) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Forehead regional oxygen saturation during resuscitation | 0-60 minutes | Oxygen saturation measured using near-infrared spectroscopy |
Countries
Finland
Outcome results
None listed