Vitamin D Deficiency
Conditions
Brief summary
To test the efficacy of different vitamin D delivery methods on serum 25(OH)D. Participants randomly assigned to one of seven groups - three placebo groups and 4 active supplement groups receiving 100,000IU vitamin D3
Detailed description
Various delivery methods of vitamin D supplementation are available to consumers but there have been no studies providing evidence of whether one delivery method is superior to others. The researchers wanted to compare the delivery of 100,000IU vitamin D3 by three methods on serum 25(OH)D levels. Two methods of oral supplementation (pill \[prolonged release\] and liquid \[immediate release\]), and delivery through the skin (with and without a penetrator enhancer. Placebo groups were pill, oral liquid and skin applied oil
Interventions
DIETARY_SUPPLEMENTvitamin D3
100,000IU
DIETARY_SUPPLEMENTPill
Dicalcium phosphate, microcrystalline cellulose, silicium dioxide, magnesium stearate
DIETARY_SUPPLEMENTorange syrup
100 drops orange syrup
OTHERmineral oil
Paraffinum Liquidum,Isopropyl Palmitate,Parfum
DIETARY_SUPPLEMENTPenetrator
Tangerine essential oil (10ml)
Sponsors
Royal National Orthopaedic Hospital NHS Trust
University of Worcester
University of Wolverhampton
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy, female
Exclusion criteria
* any participant that was taking vitamin supplementation, had a skin condition that would prevent them from applying oil to their skin or were taking, or had been taking in the past 6-months, oestrogen based contraception
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| serum 25(OH)D | 4 weeks | Changes in serum 25(OH)D levels |
Countries
United Kingdom
Outcome results
None listed