Misoprostol Before and After Cesarean Section

The Effect of Misoprostol Given Preoperative Versus Postoperative on Blood Loss With Elective Cesarean Section: Randomized Controlled Trial

Status

UNKNOWN

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03463070

Enrollment

140

Registered

2018-03-13

Start date

2018-03-31

Completion date

2018-09-30

Last updated

2018-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Partum Hemorrhage

Keywords

misoprostol, postpartum haemorrhage

Brief summary

comparison of the effect of misoprostol before and after cesarean on the blood loss

Detailed description

70 women who received 600 mg misoprostol rectally preoperatively versus 70 women who received 600 mg misoprostol postoperatively at operating theatre

Interventions

DRUGrectal misoprostol 600mg

70 women who received 600 mg misoprostol postoperatively at operating theatre

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 35 Years

Healthy volunteers

Inclusion criteria

* Women not in active labor have reactive non-stress test. * No contraindications to prostaglandins. * Have no history of coagulopathy.

Exclusion criteria

* Placenta previa. * Maternal hypertension. * Diabetes mellitus. * Previous CS and those with active labor. * Multiple Fibroid uterus. * Multiple pregnancies or polyhydramnios. * Previous myomectomy, previous history of PPH.

Design outcomes

Primary

Measure	Time frame	Description
intraoperative blood loss	the operation time	Difference in weight of linen towels (gm)+Volume of contents of suction bottle (ml)
postoperative blood loss	every 6 hours during first 24 hours.	weighing the soaked napkins after collection of soaked towel

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026