Elderly Women, Sarcopenia
Conditions
Keywords
elderly, sarcopenia, dietary supplementation, omega-3 fatty acid
Brief summary
Both aging and other factors associated with it may contribute to the development of sarcopenia, such as lack of physical activity, inadequate food intake, hormonal changes and age-related increases in cytokine levels. What is a growing number of elderly people in Brazil and the world, it is extremely important to conduct research in order to know the mechanisms of action of new strategies to combat sarcopenia. Supplementation with omega-3 fatty acids is a promising intervention in sarcopenic rest. However, there is a practice of studies confirming the effects of omega-3 fatty acid supplementation on neuromuscular function in the elderly.
Detailed description
The aim of this study is to investigate the effect of omega 3 polyunsaturated fatty acid supplementation on the muscular adaptive response in sarcopenic elderly women submitted to resistance training. A total of 30 sarcopenic elderly women, aged 65 years or older, were divided into two groups of 15 volunteers: (1) Exercise group and placebo (GEP) and (2) Exercise group and fish oil (GEOP). The two groups underwent a resisted exercise program over 12 weeks in three weekly sessions supervised by physicists and physicists at the School of Physical Education and Sports of Ribeirão Preto (EEFERP). All volunteers (both groups) are also instructed to ingest two food supplement capsules at each main meal, and the GEP group will use capsules composed of sunflower oil as a placebo. The GEOP is directed to take two capsules of fish oil at each main meal, totaling 4 capsules per day, that is, four grams of fish oil. To check the quadriceps muscle volume before and after an intervention, as volunteers from both groups are submitted to MRI. An extension power and isokinetic force of extension of the lower limb at a knee and hip extension and are measured by dynamometry (Biodex 4 Pro, Biodex, USA) and a functional solution evaluated by the application of the 6-minute walk test. In addition, will be described the biochemicals for the quantification of the following cytokines: IL1, IL6, IL8, IL10 and TNF-α, such as to allow selection of the presence of inflammation.
Interventions
DRUGFish oil
4g of fish oil daily for 14 weeks
DRUGsunflower oil
4g of sunflower oil daily for 14 weeks
Sponsors
Eduardo Ferriolli
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
65 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Being sedentary (moderate to vigorous physical activity for at least 3 months) * BMI \<30.00 kg / m2;
Exclusion criteria
* Any type of absolute and / or relative contraindication to moderate or intense physical activity. * Any physical limitation that makes it impossible to practice physical activities and / or that impairs the performance of the tests. * Also not included are those volunteers who do not go through pre-Physical Activity evaluation. (Par Q Questionnaire) * miss more than 3 workouts consecutive
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline muscle volume after 14 weeks | before and after 14 weeks | Calculated by Nuclear Magnetic Resonance |
| Change from Baseline muscle strength of knee extensors after 14 weeks | before and after 14 weeks | Measure of muscle strength of the lower limbs (knee extension) with a isokinetic dynamometer (Biodex 4 Pro) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of serum levels of inflammatory cytokines | before and after 14 weeks | Evaluated by blood samples |
| Assessment of physical performance | before and after 14 weeks | The physical performance will be evaluated by the Short Physical Performance Battery test. |
| Assessment of handgrip strength | before and after 14 weeks | Measure of handgrip strength with a manual dynamometer (Saehan) |
| Physical Activity behaviour | before and after 14 weeks | use of a tri-axial accelerometer to measure profile of spontaneous physical activity |
Countries
Brazil
Contacts
Primary ContactNatália Maira da C Alves, Master
Backup ContactKarina Pfrimer, PhD
Outcome results
None listed