Coronary Heart Disease
Conditions
Keywords
methylation, hydroxymethylation, atherosclerosis, coronary heart disease
Brief summary
The purpose of this trial is to investigate the relationship between DNA methylation and hydroxymethylation and the expression of DNMTs, TET family gene and the degree of coronary heart disease.
Detailed description
1. To determine the levels of DNA methylation and hydroxymethylation with coronary heart disease. 2. To investigate the relationship between DNA methylation and hydroxymethylation and the degree of coronary atherosclerosis.
Interventions
None listed
Sponsors
Chongqing Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Male and Female. Patients older than 65 years old who are willing to participate in the study. CHD patients was defined as at least one lesion in a coronary artery or branches in coronary angiograms. Control group was defined as people with negative findings in coronary angiograms.
Exclusion criteria
Patients with concurrent infection or any documented inflammatory illness, such as arthritis or connective tissue diseases, or any other malignancy. Patients with a history of cardiomyopathy. Pregnant women. Severe hepatic dysfunction or End-stage renal failure. Uncontrolled hypertension.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| DNA Methylation and Hydroxymethylation Levels | 1 month | Collection of blood samples and measuring the samples by PCR and ELISA |
Countries
China
Outcome results
None listed