Neonatal Hypoxia and Asphyxia
Conditions
Brief summary
Patients were classified into two equal groups using the presence or absence of hypertension during pregnancy into: hypertensive group (BP\>140/90) and normotensive group (BP≤140/90. The surgical time intervals are assessed and classified the patients accordingly into short and log time interval subgroups (induction of regional anesthesia to delivery (I-D), initial skin incision to delivery (S-D), and uterine incision to delivery (U-D)
Detailed description
Surgical times components; induction of regional anesthesia till delivery (I-D interval); incision of the skin till delivery (S-D interval); and incision of the uterus till delivery (U-D interval)) were recorded using a stopwatch. Immediately after delivery, umbilical cords were clamped on both ends and an arterial blood sample was collected anaerobically in a pre-heparinized insulin syringe. PH, base excess (BE), carbon dioxide pressure (PCO2), Oxygen pressure (PO2) and Bicarbonate (HCO3) levels were measured at 37oC by pH and gas analyzer (Gem, Premier3000, USA). The gas analysis was done in less than 30 minutes after sampling. Apgar score was assessed by a neonatologist at the 1st and 5th minutes after birth . Advanced resuscitation included positive pressure ventilation, chest compression and/or drugs administration. All resuscitated babies were transferred to neonatal intensive care unit for post resuscitation care. Fetal distress was defined by an umbilical cord pH \<7.12
Interventions
PROCEDURECesarean section
Lower segment elective Cesarean section
Sponsors
Cairo University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* full term pregnancy * singleton pregnancy * no medical disorders except hypertension in group 2
Exclusion criteria
* Multiple pregnancies * complicated pre-eclamptic cases as placental abruption, eclampsia or HELLP syndrome, * preterm pregnancies, * true knots of the cord * reduced liquor, * in labour patients, * fetal distress * infants with major congenital malformations
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| umbilical cord Ph | immediately after delivery | umbilical cords were clamped on both ends and an arterial blood sample was collected anaerobically in a pre-heparinized insulin syringe |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Apgar score | 1 and 5 minutes after delivery | assessment of Appearance, Pulse, Grimace, Activity, and Respiration |
Countries
Egypt
Outcome results
None listed