Nonalcoholic Fatty Liver Disease
Conditions
Keywords
Aerobic Exercise, Whole Body Vibration Therapy
Brief summary
Purpose of the study will investigate the effects of two different training programs on hepatic steatosis and physical fitness parameters. This trial is designed in a randomized controlled study plan and aerobic training (40 minutes) wil be combined with Whole Body Vibration Training (WBVT for 15 minutes) which is made up of a shorter time application. WBVT to be applied instead of the resistance exercises.
Interventions
OTHERAerobic Exercise
Aerobic exercise wil be held for 40 minutes. Dynamic exercises will be accompanied by physiotherapist on the vibration platform for 15 minutes. Same excercises will be held stable platform (when the devices turned off) by control group for 15 minutes.
Sponsors
Marmara University
Medipol University
Okan University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of NAFLD * Age range of 18-65 years * Participants who are not in an active exercise program * Participants who are not on an active diet program
Exclusion criteria
* Pregnancy * Chronic inflammatory process * Rheumatic disease * Cognitive disorders * Obstacles to achieve physical performance tests * Presence of other conditions that may cause liver steatosis * Inability to do WBVT or Aerobic Exercises
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| FibroScan | 8 weeks | İn the Fibroscan measurement session, the patient lying supine, the tip of the transducer is placed on the skin between the ribs over the right lobe of the liver. At least 10 validated measurements with a ratio of interquartile range (IQR) and median LSM of less than or equal to 30 percent are required for an interpretation of significant fibrosis or cirrhosis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Profile of liver enzymes | 8 weeks | Serum liver enzymes ALT, AST, GGT, ALP will be recorded. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Body composition | 8 weeks | Body mass index (BMI) will be calculated by dividing weight (kg) by height (m2). The BMI Categories will be done as follows: Underweight = \<18.5 Normal weight = 18.5-24.9 Overweight = 25-29.9 Obesity = BMI of 30 or greater |
| Cardiopulmonary exercise testing | 8 weeks | Cardiopulmonary exercise testing (CPET) will be done.The goal of testing is to evaluate the physiologic response of the heart, lungs and muscles to an increase in physical stress. Cardiopulmonary exercise testing (CPET) with cycle ergometer. The following values will be calculated personally. Peak oxygen consumption Peak heart rate Metabolic equivalent Aerobic threshold Anaerobic threshold Heart rate reserve |
| Body Fat Percentage | 8 weeks | Body Fat Percentage will be calculated skinfold measures using Jackson-Pollock measurement system. The Jackson-Pollack method for evaluating body fat percentage requires three skinfold measurements. For men, measurement sites are the chest, abdomen and thigh; for women, they consist of the thigh, triceps and suprailiac crest, or just above the top of the hip bone. Body Fat Percentage Formula will be use as follows: The formula for men is: 1.10938 - (0.0008267 x the sum of the chest, abdomen and thigh measurements in millimeters) + (0.0000016 x the square of the sum of the chest, abdomen and thigh measurements in millimeters) - (0.0002574 x age) = body density The formula for women, also known as the Jackson-Pollock-Ward formula, is: 1.0994921 - (0.0009929 x the sum of the triceps, thigh and suprailiac measurements) + (0.0000023 x the square of the sum of the triceps, thigh and suprailiac measurements) - (0.0001392 x age) = body density |
Countries
Turkey (Türkiye)
Outcome results
None listed