Heart Failure
Conditions
Brief summary
The purpose of this study is to evaluate the beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade in patients with chronic heart failure.
Interventions
OTHERNo intervention
Sponsors
Tongji Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. 18 years of age or older; 2. Patients are required to have chronic heart failure (NYHA II-IV) with a left ventricular ejection fraction lower than 40%; 3. Patients are voluntary and signed informed consent.
Exclusion criteria
1. Pregnant women or plan to; 2. Participate in any drug clinical trials within 3 months; 3. Serious neurological disease (Alzheimer's disease, Parkinson syndrome, progressive lower limbs or deaf patients); 4. Previous history of cancer or tumor, or pathological examination confirmed precancerous lesions; 5. Patients refused to comply with the requirements of this study to complete the research work; 6. According to the researchers, patients can not complete the study or not to comply with the requirements of this study (because of the reasons for the management or other reasons).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiovascular death | up to 24 months |
| Heart transplantation | up to 24 months |
Secondary
| Measure | Time frame |
|---|---|
| All cause death | up to 24 months |
| Heart failure recuring | up to 24 months |
| Readmission because of cardiovascular diseases | up to 24 months |
Countries
China
Contacts
Primary ContactLi Ni, doctor
Outcome results
None listed