Gait Disorders, Neurologic, Stroke
Conditions
Keywords
transcranial direct current stimulation
Brief summary
The aim of this study is to investigate the most effective stimulation site in transcranial direct current stimulation for gait recovery after stroke. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) bihemispheric stimulation - anodal stimulation on both ipsilesional and contralesional leg area of primary motor cortex and supplementary motor area. 2) ipsilesional stimulation - anodal stimulation on ipsilesional leg area of primary motor cortex and supplementary motor area. 3) contralesional stimulation - anodal stimulation on contralesional leg area of primary motor cortex and supplementary motor area. 4) sham stimulation. Subjects will walk on treadmill for 10 minutes during transcranial direct current stimulation. Motor evoked potential and functional evaluations will be done before and after stimulation to measure the changes.
Interventions
DEVICEIpsilesional stimulation
anodal stimulation on Ipsilesional leg area of primary motor cortex and supplementary motor area for 30 minutes
anodal stimulation on contralesional leg area of primary motor cortex and supplementary motor area for 30 minutes
OTHERWalking on treadmill
walking on treadmill for 10 minutes
Sponsors
Samsung Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Chronic stroke patients with 6 months after onset. * Functional ambulation category ≥ 3
Exclusion criteria
* patients who needs assist in surface level walking * patients with mini mental status exam score under 9 * patients with implantable electronic device * metal device inside skull * history of epilepsy * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in motor evoked potential | before and after intervention (approximately 30 minutes) | measure the motor threshold and amplitude of motor evoked potential in tibialis anterior muscle. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Fugl Meyer Assessment | before and after intervention (approximately 30 minutes) | Fugl Meyer Assessment is a measurement of motor function. |
| Changes in 10 meter walking test | before and after intervention (approximately 30 minutes) | measures gait speed |
| Changes in motricity index | before and after intervention (approximately 30 minutes) | measures motor function |
| Functional ambulatory category | before and after intervention (approximately 30 minutes) | measure gait ability. 0 is impossible to gait and 6 is normal. |
| Modified ashworth scale | before and after intervention (approximately 30 minutes) | measures spasticity with scale from 0 to 3. 0 is no increase in muscle tone. 3 is considerable increase in muscle tone, passive movement difficult. |
| Timed up and go test | before and after intervention (approximately 30 minutes) | measures gait capacity and balance |
Countries
South Korea
Outcome results
None listed