Skin Aging, Wrinkles
Conditions
Brief summary
The purpose of this study is to determine the clinical efficacy of a combination of Astaxanthin (2 mg), Lycopene (1.8 mg), and d-alpha-Tocopherol (10 IU) in terms of its skin anti-aging properties. Specifically, the investigators aim to determine the increase in hydration levels of the skin, decrease in atypical skin pigmentation, and reduction of signs of photoaging, particularly facial fine lines.
Interventions
DIETARY_SUPPLEMENTAstaxanthin (2mg)+Lycopene (1.8mg)+D-Alpha-Tocopherol (10IU)
The intervention is to be taken once daily, for 12 weeks.
DIETARY_SUPPLEMENTPlacebo
The intervention is to be taken once daily, for 12 weeks.
Sponsors
United Laboratories
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
30 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy individuals age 30 to 60 years old * Fitzpatrick Skin Type I-IV * Crow's Feet Wrinkle Scale Class 1-2 * Subjects willing to provide written informed consent
Exclusion criteria
* Use of topical or oral anti-aging drug therapy 1 month prior to the study * History of allergy to cosmetics and anti-aging drugs * History of photosensitivity reactions * Any current or past medical condition, including seizures and stroke * History of pigmentation disorder such as but not limited to vitiligo and leukoderma * Immunocompromised state * Pregnant or lactating (pregnancy kit will be used to check) * Patients who have undergone laser, radiofrequency, peeling, and other procedural therapies for anti-aging in the month prior to the study. * Patients with current inflammatory or infectious skin disease on the face, or history of such in the month prior to the study. * Patients taking OCDs and other photosensitizing drugs (e.g. tetracycline). * Not willing to provide informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of subjects within each treatment group with a significant decrease in skin wrinkling measured by a validated Crow's Feet Wrinkle scale. | 12 weeks | The scale ratings are 0 for no wrinkles, 1 for very fine wrinkles, 2 for fine wrinkles, 3 for moderate wrinkles, and 4 for severe wrinkles. |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of subjects within each treatment group with a significant decrease in pigmentation measured by a mexameter. | 12 weeks |
| Proportion of subjects within each treatment group with a significant increase in skin hydration measured by a corneometer. | 12 weeks |
Countries
Philippines
Outcome results
None listed