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Targeting Cognitive Immunization in Depression

How Can Change of Dysfunctional Expectations in Major Depression be Enhanced? An Experimental Study Targeting Cognitive Immunization

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03460574
Enrollment
135
Registered
2018-03-09
Start date
2017-10-14
Completion date
2018-08-21
Last updated
2018-08-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder

Brief summary

Research has shown that people suffering from MDD tend to maintain dysfunctional expectations despite experiences that disconfirm expectations. Recently, it has been shown that this persistence of expectations is due to maladaptive information processing involving cognitive immunization. This experimental study aims at testing three different strategies to inhibit cognitive immunization, in order to enhance expectation change.

Detailed description

It appears adaptive to change one's expectations when continuously gaining expectation-disconfirming experiences; however, research has shown that people suffering from MDD have difficulty in changing their expectations after experiences that disconfirm expectations. Recently, the investigators have shown that this persistence of expectations is due to maladaptive information processing involving cognitive immunization, defined as a cognitive reappraisal of expectation-disconfirming experiences in such a way that the individual's expectations are maintained. In view of psychotherapeutic interventions aiming to modify patients' dysfunctional expectations, effective strategies to inhibit cognitive immunization strategies need to be identified. Therefore, the aim of this study was to compare different immunization-inhibiting strategies with regard to their effectivity in enhancing expectation change. For this purpose, the investigators use a standardized experimental paradigm, which was developed and validated in a previous study.

Interventions

BEHAVIORALINFORMATION

After receiving expectation-disconfirming positive performance feedback, participants receive standardized information that stresses the relevance of this experience. In particular, participants are told that the performance test they worked on is highly relevant for both professional success and personal life satisfaction.

BEHAVIORALSALIENCE

After receiving expectation-disconfirming positive performance feedback, partcipants in this condition are instructed to remember how well they performed on the performance test. Using a visual analogue scale, they were asked to specify how they performed relative to the other participants.

BEHAVIORALATTENTION

Before working on the performance test, participants are instructed to pay attention to the feedback they receive. In particular, they are asked to enter what would be a personally good result for them. It is supposed that this shift of attention increases the salience of the expectation-disconfirming feedback.

BEHAVIORALCONTROL

This group does not receive any further intervention. Instead, participants of this group pass through the standard procedure of the EXPEC paradigm.

Sponsors

Philipps University Marburg
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)

Masking description

The investigator randomly assigns participants to one of the experimental conditions. Participants are not aware which experimental condition they are allocated to.

Intervention model description

Parallel Assignment Participants are assigned to one of four experimental groups in parallel for the duration of the study

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* current diagnosis of Major Depressive Disorder * at least 18 years old * sufficient German language knowledge

Exclusion criteria

\- none

Design outcomes

Primary

MeasureTime frameDescription
Performance Expectations Scale - generalizedDirectly prior to the performance test and directly after completing the performance testChange from Baseline to Postassessment in generalized performance expectations

Secondary

MeasureTime frameDescription
Performance Expectations Scale - task-specificDirectly prior to the performance test and directly after completing the performance testChange from Baseline to Postassessment in task-specific performance expectations

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026